INT210522

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Context Info
Confidence 0.79
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 7.73
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
cleavage 3
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 12 91.28 High High
substance P 45 90.68 High High
Hippocampus 40 84.76 Quite High
amygdala 5 80.80 Quite High
metalloproteinase 40 76.60 Quite High
Central nervous system 36 69.28 Quite High
Inflammation 37 56.72 Quite High
long-term potentiation 4 23.36 Low Low
cerebral cortex 4 22.68 Low Low
Kinase C 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 667 99.40 Very High Very High Very High
Alzheimer's Dementia 455 98.28 Very High Very High Very High
Targeted Disruption 71 93.20 High High
Vascular Dementia 17 93.04 High High
Vascular Disease 3 92.32 High High
Toxicity 18 90.72 High High
Neurodegenerative Disease 83 89.32 High High
Amyloid Plaque 65 87.84 High High
Natriuresis 1 85.36 High High
Cerebral Hypoxia 1 84.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
is concerned, IDE degrades A?
Protein_catabolism (degrades) of IDE
1) Confidence 0.79 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.40 Pain Relevance 0.07
Whereas IDE was found to degrade only soluble monomeric A?
Protein_catabolism (degrade) of IDE
2) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.62 Pain Relevance 0.14
IDE cleavage of the non-amyloidogenic T40 triggered a conformational change from ?
Protein_catabolism (cleavage) of IDE in cleavage
3) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.72 Pain Relevance 0
[35], [36], we examined the ability of IDE to degrade oligomeric AChE586-599.
Protein_catabolism (degrade) of IDE
4) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.20 Pain Relevance 0
To assess the potential for interrelationships between IDE and NEP degradation, peaks e–f (see Figure 2C) from a 30 min IDE/T40 digest were subjected to NEP digestion for 2 hours.
Protein_catabolism (degradation) of IDE
5) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.06 Pain Relevance 0.03
Significant differences were observed between the degradation capability of IDE and NEP.
Protein_catabolism (degradation) of IDE
6) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0
In conclusion, we have clearly demonstrated that IDE-dependent cleavage of the non-amyloidogenic hAChE oligomerisation domain leads to a conformational switch to ?
Protein_catabolism (cleavage) of IDE in cleavage
7) Confidence 0.51 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.46 Pain Relevance 0
oligomers, IDE degraded AChE586-599 oligomers (Figure 3C), in an insulin-sensitive manner (data not shown).
Protein_catabolism (degraded) of IDE
8) Confidence 0.51 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.16 Pain Relevance 0
To identify degradation products, 60 µM T40 was incubated with 50 nM IDE; 63 µM AChE586-599 with 45 nM or 273 nM IDE; and 40 µM AChE586-599 with 772 nM NEP and separated by reverse phase-HPLC (RP-HPLC).
Protein_catabolism (degradation) of IDE
9) Confidence 0.51 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.07 Pain Relevance 0.04
We investigated the influence of IDE and NEP proteolysis on the formation and degradation of relevant hAChE ?
Protein_catabolism (proteolysis) of IDE
10) Confidence 0.38 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1920558 Disease Relevance 0.72 Pain Relevance 0.06
To determine a full map for IDE cleavage of T40, a temporal series of products were analyzed by mass spectrometry (MS) and reported based upon T40 numbering (Asp1 to Leu40).
Protein_catabolism (cleavage) of IDE in cleavage
11) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.06 Pain Relevance 0
T40-degrading activity of IDE
Protein_catabolism (degrading) of IDE
12) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.33 Pain Relevance 0.03
degradation in vivo are neprilysin (NEP), endothelin-converting enzyme (ECE)-1 and ECE-2, insulin-degrading enzyme (IDE), and plasmin.
Protein_catabolism (degradation) of IDE
13) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.38 Pain Relevance 0
degradation in vivo are neprilysin (NEP), endothelin-converting enzyme (ECE)-1 and ECE-2, insulin-degrading enzyme (IDE), and plasmin.
Protein_catabolism (degrading) of IDE
14) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.31 Pain Relevance 0
Insulin is catabolised by IDE, which also degrades other compounds such as IGFI, IGFII, amylin, intra- and extracellular A?
Protein_catabolism (degrades) of IDE
15) Confidence 0.29 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 2.41 Pain Relevance 0
formation [131] and metalloproteases, such as neprilysin and insulin-degrading enzyme (IDE), that degrade A?
Protein_catabolism (degrading) of insulin
16) Confidence 0.07 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.83 Pain Relevance 0.19

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