INT210523

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.42
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tenc1)
Anatomy Link Frequency
brain 2
Tenc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 47 98.80 Very High Very High Very High
antagonist 10 83.80 Quite High
Neuropeptide 16 79.84 Quite High
Calcitonin gene-related peptide 2 55.64 Quite High
substance P 8 54.32 Quite High
ketamine 4 52.32 Quite High
Inflammatory response 4 46.24 Quite Low
analgesia 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Edema 12 99.24 Very High Very High Very High
INFLAMMATION 41 98.80 Very High Very High Very High
Injury 92 95.68 Very High Very High Very High
Burns 88 95.40 Very High Very High Very High
Adult Respiratory Distress Syndrome 2 92.96 High High
Viral Infection 4 73.68 Quite High
Urological Neuroanatomy 30 70.52 Quite High
Disease 27 56.72 Quite High
Neurogenic Inflammation 12 54.24 Quite High
Alzheimer's Dementia 38 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this, we studied whether blocking NEP with a specific inhibitor, CGS 24592, would increase vascular leakage and edema and inflammation.


Spec (whether) Positive_regulation (increase) of Spec (whether) Negative_regulation (blocking) of NEP associated with inflammation and edema
1) Confidence 0.43 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.24 Pain Relevance 0.27
To test this, we studied whether blocking NEP with a specific inhibitor, CGS 24592, would increase vascular leakage, edema, and inflammation.
Spec (whether) Positive_regulation (increase) of Spec (whether) Negative_regulation (blocking) of NEP associated with inflammation and edema
2) Confidence 0.43 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.12 Pain Relevance 0.42
Therefore, if modification of hAChE by IDE occurs in vivo, both IDE and NEP deficiencies could alter the brain levels of CSR species and increase the risk of oligomerisation and fibril deposition.
Positive_regulation (increase) of Negative_regulation (deficiencies) of NEP in brain
3) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.06 Pain Relevance 0

General Comments

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