INT210527

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.37
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tenc1)
Anatomy Link Frequency
liver 4
plaque 2
epithelium 2
band 2
Tenc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 82 100.00 Very High Very High Very High
painful pain 9 100.00 Very High Very High Very High
Neuropeptide 8 99.98 Very High Very High Very High
Pain 111 99.52 Very High Very High Very High
medulla 11 93.56 High High
metalloproteinase 2 93.48 High High
Hippocampus 172 91.76 High High
Osteoarthritis 11 91.72 High High
Multiple sclerosis 7 83.92 Quite High
reflex sympathetic dystrophy 7 83.04 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 115 100.00 Very High Very High Very High
Syndrome 14 100.00 Very High Very High Very High
Nociception 14 100.00 Very High Very High Very High
Targeted Disruption 304 99.64 Very High Very High Very High
Pain 138 99.52 Very High Very High Very High
Amyloid Plaque 103 99.48 Very High Very High Very High
Disease 294 99.42 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 98.04 Very High Very High Very High
Alzheimer's Dementia 527 97.36 Very High Very High Very High
Smoke Inhalation Injury 12 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
degradation assays, conditioned medium from APP-overexpressing CHO cells was combined with 10-fold concentrated conditioned medium from CHO cells overexpressing empty vector, NEP, or sNEP and incubated at 37 °C for 18 h.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of NEP
1) Confidence 0.38 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.22 Pain Relevance 0
When considering the above mentioned NeP and NocP syndromes, the LANSS Pain Scale was able to correctly identify 82,4% (810/983) of patients with one pain complaint, representing 84,7% sensitivity and 80,2% specificity.


Positive_regulation (mentioned) of Gene_expression (syndromes) of NeP associated with pain, syndrome, neuropathic pain and painful pain
2) Confidence 0.38 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 2.76 Pain Relevance 1.62
Because transfected NEP may run as a broad band due to its varying degrees of glycosylation, all samples were assessed in the absence or presence of PNGase F to remove N-linked glycosylation and reduce NEP immunoreactivity to a single signal.
Positive_regulation (transfected) of Gene_expression (transfected) of NEP in band
3) Confidence 0.32 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0.09
Mouse lung and kidney express high levels of NEP that comigrates with transfected human NEP, whereas the liver lacks NEP expression (Figure 1A).
Positive_regulation (lacks) of Neg (lacks) Gene_expression (expression) of NEP in liver
4) Confidence 0.28 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.07 Pain Relevance 0.07
Both wild-type NEP and sNEP were capable of promoting A?
Positive_regulation (promoting) of Gene_expression (capable) of wild-type NEP
5) Confidence 0.28 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0
degradation assays, conditioned medium from APP-overexpressing CHO cells was combined with 10-fold concentrated conditioned medium from CHO cells overexpressing empty vector, NEP, or sNEP and incubated at 37 °C for 18 h.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of NEP
6) Confidence 0.28 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.23 Pain Relevance 0
As positive and negative controls, lysates from CHO cells transfected with NEP or empty vector control were examined in parallel.
Positive_regulation (transfected) of Gene_expression (transfected) of NEP
7) Confidence 0.28 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0.09
Mouse lung and kidney express high levels of NEP that comigrates with transfected human NEP, whereas the liver lacks NEP expression (Figure 1A).
Positive_regulation (transfected) of Gene_expression (transfected) of NEP in liver
8) Confidence 0.28 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.06 Pain Relevance 0.07
levels by elevating NEP expression, we evaluated a secreted form of NEP, sNEP.
Positive_regulation (elevating) of Gene_expression (expression) of NEP
9) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.09 Pain Relevance 0
A study using AD transgenic mice that had an over expression of IDE or NEP demonstrated a significant reduction in A?
Positive_regulation (over) of Gene_expression (expression) of NEP associated with targeted disruption and disease
10) Confidence 0.12 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.74 Pain Relevance 0
Loss of NEP function in APP mice markedly increased hippocampal amyloid plaque burden, and led to the development of amyloid angiopathy.
Positive_regulation (increased) of Gene_expression (function) of NEP in plaque associated with vascular disease, alzheimer's dementia and amyloid plaque
11) Confidence 0.11 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.91 Pain Relevance 0.03
, whereas NEP acted mainly on monomeric species (compared with monomeric and oligomeric species for A?)
Positive_regulation (whereas) of Gene_expression (acted) of NEP
12) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0
NEP gene transfer has previously been found to reduce amyloid deposits in transgenic mice [116,117].
Positive_regulation (transfer) of Gene_expression (transfer) of NEP associated with targeted disruption and amyloid plaque
13) Confidence 0.02 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.35 Pain Relevance 0.18
Restoration of control of potent neuropeptides requires the restoration of columnar epithelium with NEP production, which explains the extensive period of airways hyperactivity after smoke inhalation injury (Figure 11).112–114 Activation of clotting cascade also leads to increased fibrin production finding its way into the plugs that occlude distal airways.
Positive_regulation (requires) of Gene_expression (production) of NEP in epithelium associated with coagulation disorder, smoke inhalation injury, neuropeptide and attention deficit hyperactivity disorder
14) Confidence 0.01 Published 2008 Journal Eplasty Section Body Doc Link PMC2396464 Disease Relevance 0.93 Pain Relevance 0.29

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