INT210532

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
cleavage 2
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 40 77.04 Quite High
substance P 5 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Cholecystokinin 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
bradykinin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 68 97.44 Very High Very High Very High
Targeted Disruption 18 93.20 High High
Alzheimer's Dementia 47 87.20 High High
Natriuresis 1 85.80 High High
Toxicity 3 56.40 Quite High
Amyloid Plaque 7 34.96 Quite Low
Death 3 32.04 Quite Low
Neurodegenerative Disease 7 7.12 Low Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
is concerned, IDE degrades A?
Positive_regulation (concerned) of Protein_catabolism (degrades) of IDE
1) Confidence 0.40 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.40 Pain Relevance 0.07
In conclusion, we have clearly demonstrated that IDE-dependent cleavage of the non-amyloidogenic hAChE oligomerisation domain leads to a conformational switch to ?
Positive_regulation (dependent) of Protein_catabolism (cleavage) of IDE in cleavage
2) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.46 Pain Relevance 0

General Comments

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