INT210539

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.09
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
brain 2
Mouse 1
plaques 1
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 10 88.56 High High
Inflammation 59 81.00 Quite High
substance P 26 80.24 Quite High
adenocard 2 78.32 Quite High
Hippocampus 16 76.68 Quite High
metalloproteinase 80 72.88 Quite High
anesthesia 4 69.44 Quite High
Eae 9 62.48 Quite High
imagery 7 61.64 Quite High
ischemia 4 59.60 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 303 100.00 Very High Very High Very High
Targeted Disruption 106 100.00 Very High Very High Very High
Insulin Resistance 3 99.92 Very High Very High Very High
Amyloid Plaque 45 99.76 Very High Very High Very High
Hyperglycemia 4 99.74 Very High Very High Very High
Disease 427 99.52 Very High Very High Very High
Diabetes Mellitus 28 99.04 Very High Very High Very High
Experimental Diabetes Mellitus 1 97.04 Very High Very High Very High
Cognitive Disorder 84 92.56 High High
Sprains And Strains 7 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in conditioned medium from neuronal cultures [93], and both rat and mouse IDE knockout animals exhibit enhanced brain A?
IDE Binding (exhibit) of in brain associated with targeted disruption
1) Confidence 0.29 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.43 Pain Relevance 0.07
In AD-afflicted human brain, IDE is associated with senile plaques and A?
IDE Binding (associated) of in plaques associated with disease and amyloid plaque
2) Confidence 0.28 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.90 Pain Relevance 0
Upon binding to IDE, substrates undergo drastic conformational changes from ?
IDE Binding (binding) of
3) Confidence 0.28 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.24 Pain Relevance 0
IDE cleaves a broad range of peptides and has been proposed to be an amyloid scavenger recognizing structural ?
IDE Binding (recognizing) of associated with alzheimer's dementia
4) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 1.07 Pain Relevance 0.09
In our case, the surfactant and amyloidogenic CSR species generated by IDE might lead to an increased concentration of potentially toxic oligomeric forms, whether these are homo-oligomers of ?
IDE Binding (generated) of
5) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.29 Pain Relevance 0
Some peptides were generated by both NEP and IDE (e.g.
IDE Binding (generated) of
6) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0.04
While the CSR peptides themselves may offer a potential target in the struggle to prevent abnormal protein aggregation in the brain, our results suggest that simply increasing IDE and NEP activity may not be as beneficial as anticipated.
IDE Binding (activity) of in brain
7) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.35 Pain Relevance 0
IDE has been proposed to be an amyloid scavenger recognizing structural ?
IDE Binding (recognizing) of associated with alzheimer's dementia
8) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.28 Pain Relevance 0
Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Diabetes mellitus (DM) is characterized by hyperglycemia caused by a lack of insulin, insulin resistance, or both.

insulin Neg (lack) Binding (lack) of in Mouse associated with hyperglycemia, targeted disruption, diabetes mellitus, experimental diabetes mellitus, insulin resistance and disease
9) Confidence 0.12 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2775636 Disease Relevance 1.54 Pain Relevance 0.03
binds to insulin receptors and affects its autophosphorylation in the presence of insulin.
insulin Binding (binds) of
10) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938309 Disease Relevance 0.33 Pain Relevance 0.12
This is an important finding because it represents an uncoupling of both insulin and neurotrophic factor signaling to the critical neuroprotective PI3-K/Akt pathway [161].DHA modestly suppressed A?
insulin Binding (uncoupling) of
11) Confidence 0.02 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.58 Pain Relevance 0.07
K6219, DAKO), in which the primary pig anti-insulin antibody does not cross-react with mouse insulin, was used, according to the manufacturer's instructions, to follow pig insulin levels.
insulin Binding (react) of
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.06 Pain Relevance 0.10

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