INT210566

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.15
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMC4) nucleoplasm (PSMC4) mitochondrion (PSMC4)
small molecule metabolic process (PSMC4) nucleolus (PSMC4) ATPase activity (PSMC4)
PSMC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 12 96.40 Very High Very High Very High
addiction 23 87.32 High High
sSRI 2 63.28 Quite High
Serotonin 19 61.80 Quite High
tricyclic antidepressant 7 50.00 Quite Low
potassium channel 1 50.00 Quite Low
Inflammatory marker 1 19.12 Low Low
Morphine 49 5.00 Very Low Very Low Very Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
Action potential 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 67 96.12 Very High Very High Very High
Dengue 63 91.36 High High
Thrombocytopenia 1 70.64 Quite High
Infection 32 60.04 Quite High
Convalescence 3 54.64 Quite High
INFLAMMATION 1 19.12 Low Low
Shock 12 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 4 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Table S5 and Table S6 present the raw Ki data converted into npKi values, for both the individual receptors, and groups of receptors summed using the Bsq statistic.


Gene_expression (present) of S6
1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814854 Disease Relevance 0 Pain Relevance 0.05
Using GO analysis, the biological processes enriched in genes differentially expressed by DSS patients were found to include protein metabolism and modification, intracellular protein traffic, pre-mRNA processing, mRNA splicing, nuclear transport, protein-lipid modification and protein folding (Table S6 and Table S7).
Gene_expression (folding) of S6 associated with dengue hemorrhagic fever
2) Confidence 0.09 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.15 Pain Relevance 0
For the majority of drugs that have been studied, one or both of the Y652 and F656 aromatic amino acid residues in the S6 helices of the HERG channel comprise key elements of the drug binding site [5,9,38,51].
Gene_expression (helices) of S6
3) Confidence 0.04 Published 2007 Journal Biochem Pharmacol Section Body Doc Link PMC1920586 Disease Relevance 0 Pain Relevance 0.21

General Comments

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