INT210568

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (KCNH2) plasma membrane (KCNH2) transmembrane transport (KCNH2)
cytoplasm (KCNH2)
KCNH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 23 81.96 Quite High
sSRI 2 57.92 Quite High
Serotonin 1 56.44 Quite High
tricyclic antidepressant 7 50.00 Quite Low
potassium channel 1 50.00 Quite Low
Potency 8 33.12 Quite Low
Action potential 8 5.00 Very Low Very Low Very Low
Endep 7 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
antiarrhythmic agent 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 4 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Syncope 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Sudden Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the Y652A and F656A mutations increased the IC50 for HERG blockade by the methanesulphonanilide MK-499 by 94-fold and 650-fold, respectively, and that for terfenadine by ?
Positive_regulation (increased) of Localization (blockade) of HERG
1) Confidence 0.38 Published 2007 Journal Biochem Pharmacol Section Body Doc Link PMC1920586 Disease Relevance 0 Pain Relevance 0.21

General Comments

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