INT210569

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (KCNH2) plasma membrane (KCNH2) transmembrane transport (KCNH2)
cytoplasm (KCNH2)
KCNH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 2 67.36 Quite High
tricyclic antidepressant 7 50.00 Quite Low
potassium channel 2 50.00 Quite Low
addiction 26 13.20 Low Low
Action potential 48 5.00 Very Low Very Low Very Low
action potential duration 20 5.00 Very Low Very Low Very Low
lidocaine 9 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
Endep 7 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 4 50.00 Quite Low
Disease 2 31.20 Quite Low
Congenital Anomalies 2 26.24 Quite Low
Myocardial Infarction 2 17.36 Low Low
Arrhythmias 2 Under Development 3 15.28 Low Low
Arrhythmia Under Development 13 5.00 Very Low Very Low Very Low
Syndrome 11 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Heart Rate Under Development 4 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M (shown in Fig. 1 to produce extensive inhibition of WT IHERG with a standard [K+]e).
Negative_regulation (inhibition) of Gene_expression (produce) of HERG
1) Confidence 0.41 Published 2007 Journal Biochem Pharmacol Section Body Doc Link PMC1920586 Disease Relevance 0 Pain Relevance 0
Microvolt TWA has been observed after administration of pentamidine (KrollĀ & Gettes 2002), which can prolong the QT interval by reducing hERG expression (Cordes et al. 2005), and thus proposed to be potentially useful for identification of patients who exhibit higher risk for lethal arrhythmias.
Negative_regulation (reducing) of Gene_expression (expression) of hERG
2) Confidence 0.01 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0 Pain Relevance 0.03

General Comments

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