INT210571

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.70
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNE2) lysosome (KCNE2)
Anatomy Link Frequency
cardiac conduction system 1
KCNE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 22 99.88 Very High Very High Very High
Action potential 46 98.36 Very High Very High Very High
Potency 16 90.16 High High
sodium channel 34 75.12 Quite High
Mexiletine 33 66.96 Quite High
tricyclic antidepressant 14 50.00 Quite Low
lidocaine 4 48.60 Quite Low
action potential duration 4 31.92 Quite Low
addiction 56 5.00 Very Low Very Low Very Low
Endep 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 388 99.04 Very High Very High Very High
Congenital Anomalies 22 96.64 Very High Very High Very High
Sudden Death 32 76.12 Quite High
Syncope 51 75.44 Quite High
Disease 88 59.92 Quite High
Channelopathies 9 58.52 Quite High
Andersen Syndrome 18 19.40 Low Low
Targeted Disruption 2 19.04 Low Low
Arrhythmia Under Development 27 14.64 Low Low
Deafness 8 13.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The KCNH2 gene and the KCNE2 gene encode respectively the alpha (HERG – Human Ether-a-go-go Related Gene) and the ?
Gene_expression (gene) of KCNE2
1) Confidence 0.61 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 0.84 Pain Relevance 0.12
Mutations in the KCNE2 gene are found in the LQT6 variant of LQTS.
Gene_expression (found) of KCNE2 associated with syndrome
2) Confidence 0.54 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 0.66 Pain Relevance 0.07
subunit of the IKS potassium channel), or KCNE2 (codes for the ?
Gene_expression (codes) of KCNE2 associated with potassium channel
3) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.32 Pain Relevance 0.08
LQT2, LQT6: KCNH2 (LQT2) and KCNE2 (causing LQT6) gene encode respectively for the alpha (HERG) and the beta (MiRP) subunits of the potassium channel conducting the IKr current the rapid component of the cardiac delayed rectifier.
Gene_expression (causing) of KCNE2 associated with potassium channel
4) Confidence 0.17 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.29 Pain Relevance 0.10
LQT2, LQT6: KCNH2 (LQT2) and KCNE2 (causing LQT6) gene encode respectively for the alpha (HERG) and the beta (MiRP) subunits of the potassium channel conducting the IKr current the rapid component of the cardiac delayed rectifier.
Gene_expression (causing) of LQT6 associated with potassium channel
5) Confidence 0.17 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.30 Pain Relevance 0.11
LQT2, LQT6: KCNH2 (LQT2) and KCNE2 (causing LQT6) gene encode respectively for the alpha (HERG) and the beta (MiRP) subunits of the potassium channel conducting the IKr current the rapid component of the cardiac delayed rectifier.
Gene_expression (causing) of LQT6 associated with potassium channel
6) Confidence 0.17 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.29 Pain Relevance 0.10
Although we did not co-express HERG with MiRP1, a putative ?
Gene_expression (express) of MiRP1
7) Confidence 0.14 Published 2007 Journal Biochem Pharmacol Section Body Doc Link PMC1920586 Disease Relevance 0 Pain Relevance 0.19
subunit suggested to be necessary to recapitulate native IKr [55], it has recently been suggested that MiRP1 is unlikely to interact with HERG outside of the cardiac conduction system [51] and, additionally, the pharmacological sensitivity of HERG channels expressed in mammalian cells without MiRP1 co-expression has been found to be similar to that of native IKr [56].
Gene_expression (expression) of MiRP1 in cardiac conduction system
8) Confidence 0.14 Published 2007 Journal Biochem Pharmacol Section Body Doc Link PMC1920586 Disease Relevance 0 Pain Relevance 0.19

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