INT210593

Context Info Confidence 0.10 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.62 Pain Relevance 0.04

signal transduction (TNFRSF11B, TNFRSF11A) extracellular region (TNFRSF11B, TNFSF11) cell differentiation (TNFSF11) intracellular (TNFSF11) extracellular matrix organization (TNFRSF11B) cell-cell signaling (TNFRSF11A)

Anatomy Link Frequency osteoclasts 2 TNFRSF11B (Homo sapiens) TNFSF11 (Homo sapiens) TNFRSF11A (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 6 77.04 cva 11 18.24 antagonist 5 5.00 Potency 3 5.00 withdrawal 2 5.00 Bioavailability 2 5.00 metalloproteinase 2 5.00 tolerance 2 5.00 chemokine 2 5.00 headache 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 7 98.64 Necrosis 3 93.32 Cancer 68 92.96 Hypercalcemia 25 84.96 Osteoporosis 125 83.72 Metastasis 93 80.64 Disorders Of Creatine Metabolism 2 75.20 Renal Failure 1 73.88 Alopecia 1 67.92 Syndrome 5 59.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

OPG is a negative regulator of the RANK/RANKL pathway and prevents RANK-RANKL interaction by sequestering RANKL.

OPG Negative_regulation (prevents) of RANKL Binding (interaction) of RANK

1) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 0.77 Pain Relevance 0.04

OPG competitively inhibits the binding of RANKL to RANK on osteoclasts and their precursors.

OPG Negative_regulation (inhibits) of RANKL Binding (binding) of RANK in osteoclasts

2) Confidence 0.02 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.85 Pain Relevance 0

General Comments

This test has worked.