INT210596

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.62
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TNFRSF11B, TNFSF11) cell differentiation (TNFSF11) intracellular (TNFSF11)
extracellular matrix organization (TNFRSF11B) response to stress (TNFSF11) cytoplasm (TNFSF11)
Anatomy Link Frequency
osteoclasts 2
TNFRSF11B (Homo sapiens)
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 77.04 Quite High
cva 11 18.24 Low Low
antagonist 5 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 7 98.64 Very High Very High Very High
Necrosis 3 93.32 High High
Cancer 68 92.96 High High
Hypercalcemia 25 84.96 Quite High
Osteoporosis 125 83.72 Quite High
Metastasis 93 80.64 Quite High
Disorders Of Creatine Metabolism 2 75.20 Quite High
Renal Failure 1 73.88 Quite High
Alopecia 1 67.92 Quite High
Syndrome 5 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OPG is a negative regulator of the RANK/RANKL pathway and prevents RANK-RANKL interaction by sequestering RANKL.
OPG Negative_regulation (prevents) of RANKL Binding (interaction) of
1) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 0.77 Pain Relevance 0.04
OPG competitively inhibits the binding of RANKL to RANK on osteoclasts and their precursors.
OPG Negative_regulation (inhibits) of RANKL Binding (binding) of in osteoclasts
2) Confidence 0.06 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.85 Pain Relevance 0

General Comments

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