INT210598

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.98
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (PTHLH, TNFSF11) cytoplasm (PTHLH, TNFSF11) extracellular space (PTHLH, TNFSF11)
extracellular region (PTHLH, TNFSF11) cell differentiation (TNFSF11) Golgi apparatus (PTHLH)
Anatomy Link Frequency
osteoblasts 2
PTHLH (Homo sapiens)
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 87.68 High High
antagonist 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteolysis 16 100.00 Very High Very High Very High
Metastasis 92 99.72 Very High Very High Very High
Hypercalcemia 3 98.48 Very High Very High Very High
Breast Cancer 12 97.60 Very High Very High Very High
Osteoporosis 45 94.16 High High
Prostate Cancer 17 89.60 High High
Cancer 66 86.36 High High
Apoptosis 5 79.72 Quite High
Disease Progression 1 15.00 Low Low
Lung Cancer 4 9.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTHrP contributes to osteolysis by upregulating expression of RANKL on osteoblasts [26,41].
PTHrP Positive_regulation (upregulating) of Gene_expression (expression) of RANKL in osteoblasts associated with osteolysis
1) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 0.98 Pain Relevance 0.04

General Comments

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