INT2106

Context Info Confidence 0.62 First Reported 1975 Last Reported 2010 Negated 60 Speculated 30 Reported most in Abstract Documents 279 Total Number 312 Disease Relevance 22.37 Pain Relevance 122.77

Anatomy Link Frequency pituitary 29 brain 20 hypothalamus 18 MPOA 14 gonadal 14 LH (Rattus norvegicus)

Pain Link Frequency Relevance Heat narcan 925 100.00 antagonist 503 100.00 agonist 312 100.00 opiate 307 100.00 Morphine 289 100.00 Opioid 231 100.00 Dopamine 154 100.00 gABA 139 100.00 Endogenous opioid 111 100.00 Glutamate 95 100.00

Disease Link Frequency Relevance Heat Stress 530 100.00 Urological Neuroanatomy 78 100.00 Galactorrhea 48 100.00 Diabetes Mellitus 34 100.00 Hypoglycemia 19 100.00 Aids-related Complex 18 100.00 Decapitation 4 99.98 Natriuresis 57 99.12 Nociception 2 99.12 Body Weight 130 99.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The role of brain catecholamines in controlling tonic LH secretion was studied in unanesthesized, freely moving, ovariectomized rats.

Regulation (controlling) of Localization (secretion) of LH in brain associated with catecholamine

1) Confidence 0.62 Published 1981 Journal Endocrinology Section Abstract Doc Link 6258902 Disease Relevance 0 Pain Relevance 0.19

The apparent advance in the onset of puberty is discussed in terms of the opioid hypothalamic activity as a mechanism that affects the LH secretion.

Regulation (affects) of Localization (secretion) of LH associated with opioid

2) Confidence 0.62 Published 2000 Journal Alcohol Section Abstract Doc Link 10963936 Disease Relevance 0 Pain Relevance 0.21

The effects of pentobarbital (PBTL) on pulsatile LH release in ovariectomized rats were studied and characterized.

Regulation (effects) of Localization (release) of LH

3) Confidence 0.62 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 732952 Disease Relevance 0 Pain Relevance 0.13

The effect of an ovulation-blocking methadone treatment (5mg/kg s.c. at 13:00, 14:00 and 15:00) on preovulatory LH release was studied in Wistar and Sprague-Dawley rats.

Regulation (effect) of Localization (release) of LH associated with methadone

4) Confidence 0.62 Published 1978 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 565942 Disease Relevance 0 Pain Relevance 0.36

Opiatergic control of LH secretion is eliminated by gonadectomy.

Regulation (control) of Localization (secretion) of LH associated with enkephalin

5) Confidence 0.62 Published 1983 Journal Endocrinology Section Title Doc Link 6291922 Disease Relevance 0 Pain Relevance 0.54

Recent studies have demonstrated that ovarian steroids are involved in the regulation of pulsatile LH secretion.

Regulation (regulation) of Localization (secretion) of LH

6) Confidence 0.62 Published 1985 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 3996684 Disease Relevance 0.13 Pain Relevance 0.06

Rats with the EB implant in the bed nucleus of the stria terminaris, the medial preoptic area, the medial septal nucleus or the anterior hypothalamic area did not show any changes in either the amplitude or the frequency of pulsatile LH secretion.

Neg (not) Regulation (changes) of Localization (secretion) of LH in preoptic area associated with urological neuroanatomy

7) Confidence 0.62 Published 1985 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 3996684 Disease Relevance 0.10 Pain Relevance 0.04

Studies were undertaken to develop a naloxone implant capable of chronically blocking opioid receptors for several weeks in an effort to evaluate the effect of this prolonged narcotic antagonism on luteinizing hormone (LH) secretion in female rats.

Regulation (effect) of Localization (secretion) of LH associated with narcan and opioid receptor

8) Confidence 0.62 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6139759 Disease Relevance 0 Pain Relevance 0.73

The effect of Naltrexone (Nalt), a specific opiate receptor blocker, on LH secretion was studied at frequent intervals during the first hour following treatment.

Regulation (effect) of Localization (secretion) of LH associated with opiate

9) Confidence 0.62 Published 1987 Journal Life Sci. Section Abstract Doc Link 3600195 Disease Relevance 0.30 Pain Relevance 0.17

Opiate system involvement in the control of LH secretion in diabetic and normoglycemic male rats.

Regulation (control) of Localization (secretion) of LH associated with diabetes mellitus and opiate

10) Confidence 0.62 Published 1987 Journal Life Sci. Section Title Doc Link 3600195 Disease Relevance 0.42 Pain Relevance 0.25

On the other hand, PM cuts did not affect the suppressive action of the alpha-adrenoblocker phenoxybenzamine on the norepinephrine-induced release of LH.

Neg (not) Regulation (affect) of Localization (release) of LH

11) Confidence 0.62 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6813756 Disease Relevance 0 Pain Relevance 0.09

Studies were undertaken to determine the effects of chronic stimulation of opiate receptors on the negative feedback effects of testosterone (T) on luteinizing hormone (LH) secretion in the male rat.

Spec (determine) Regulation (effects) of Localization (secretion) of LH associated with opiate

12) Confidence 0.62 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2982110 Disease Relevance 0.07 Pain Relevance 0.27

From these data we conclude that (1) neonatal testosterone treatment alters noradrenergic-opioid interaction regulating LH secretion in adult females and (2) the site of this change may be the presynaptic opioid input to the noradrenergic terminals in the MPOA.

Regulation (regulating) of Localization (secretion) of LH in MPOA associated with urological neuroanatomy and opioid

13) Confidence 0.61 Published 1987 Journal Brain Res. Section Abstract Doc Link 3607492 Disease Relevance 0.25 Pain Relevance 0.74

Pretreatment with a peripherally acting epinephrine (EPI) synthesis inhibitor, SK&F 29661, failed to influence the naloxone-induced LH release.

Neg (failed) Regulation (influence) of Localization (release) of LH in EPI associated with narcan

14) Confidence 0.61 Published 1982 Journal Endocrinology Section Abstract Doc Link 7117202 Disease Relevance 0 Pain Relevance 0.39

In female rat age-related reproductive decline is accompanied by progressive impairment of the neuroendocrine mechanisms that regulate LH secretion.

Regulation (regulate) of Localization (secretion) of LH

15) Confidence 0.61 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1436374 Disease Relevance 0.15 Pain Relevance 0.03

A 'window of time' during which testosterone determines the opiatergic control of LH release in the adult male rat.

Spec (determines) Regulation (control) of Localization (release) of LH

16) Confidence 0.61 Published 1987 Journal J. Reprod. Fertil. Section Title Doc Link 3820180 Disease Relevance 0 Pain Relevance 0.45

The effect of naloxone on the negative feedback action of gonadal steroids on luteinizing hormone (LH) release was studied in castrated male and female rats.

Regulation (effect) of Localization (release) of LH in gonadal associated with narcan

17) Confidence 0.61 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 7041002 Disease Relevance 0 Pain Relevance 0.19

The effects of morphine on the secretion of luteinizing hormone (LH) were examined in male rats at intervals after castration.

Regulation (effects) of Localization (secretion) of LH associated with morphine

18) Confidence 0.61 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7143239 Disease Relevance 0 Pain Relevance 0.53

These data seem to indicate that hypothalamic mu receptors may be involved in the positive but not in the negative feedback control of LH secretion.

Regulation (control) of Localization (secretion) of LH

19) Confidence 0.61 Published 1991 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 1659872 Disease Relevance 0 Pain Relevance 0.08

To test this hypothesis the effects of transiently decreasing the opioid tone with an opiate receptor antagonist, naloxone (NAL), on LH secretion in estrogen-primed, short term (5 days) and long term (4 weeks) ovx rats were examined.

Regulation (effects) of Localization (secretion) of LH associated with antagonist, narcan, opiate and opioid

20) Confidence 0.61 Published 1990 Journal Endocrinology Section Abstract Doc Link 2293982 Disease Relevance 0 Pain Relevance 0.73

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