INT210601

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.46
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL8, TNFSF11) extracellular region (IL8, TNFSF11) intracellular (IL8, TNFSF11)
cell differentiation (TNFSF11) signal transduction (IL8) plasma membrane (TNFSF11)
Anatomy Link Frequency
osteoclast 1
IL8 (Homo sapiens)
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 94.24 High High
antagonist 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 92 91.36 High High
Osteolysis 16 88.48 High High
Osteoporosis 45 87.76 High High
Cancer 66 86.20 High High
Lung Cancer 4 54.00 Quite High
Prostate Cancer 17 13.96 Low Low
Breast Cancer 12 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Hypercalcemia 3 5.00 Very Low Very Low Very Low
Multiple Myeloma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bendre and coworkers [47] demonstrated that IL-8 binds to CXCR1 present on osteoclast precursors and enhances osteoclast differentiation independent of RANKL.
IL-8 Neg (independent) Positive_regulation (independent) of RANKL in osteoclast
1) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.46 Pain Relevance 0.08

General Comments

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