INT210605

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TNFSF11) extracellular space (TNFSF11) extracellular region (TNFSF11)
plasma membrane (TNFSF11) intracellular (TNFSF11) response to stress (TNFSF11)
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 1 74.00 Quite High
Osteoarthritis 66 63.36 Quite High
cytokine 10 55.48 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 67 100.00 Very High Very High Very High
Osteoporosis 61 98.84 Very High Very High Very High
Osteolysis 16 97.60 Very High Very High Very High
Metastasis 92 93.84 High High
Lung Cancer 4 77.12 Quite High
Prostate Cancer 17 76.28 Quite High
Hypercalcemia 10 66.28 Quite High
Breast Cancer 12 65.40 Quite High
Osteoarthritis 66 63.36 Quite High
Apoptosis 6 47.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the OPG and RANKL system, our data revealed that CS can modulate the expression of these molecules by increasing OPG and decreasing the gene expression level of RANKL, thereby increasing the mRNA ratio of OPG/RANKL.
Negative_regulation (decreasing) of Negative_regulation (decreasing) of RANKL
1) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.06 Pain Relevance 0.07
However, blocking the OPG/RANK/RANKL pathway with RANK-Fc had no effect on tumor cells in nonosseous sites; the decrease in tumor burden following inhibition of the tumor-mediated osteolysis is an indirect effect secondary to interruption of the vicious cycle of osteolytic metastasis [43-45].
Negative_regulation (blocking) of Negative_regulation (decrease) of RANKL associated with cancer, osteolysis and metastasis
2) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.59 Pain Relevance 0.03

General Comments

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