INT210606

Context Info Confidence 0.19 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 2.70 Pain Relevance 0.03

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency stromal cells 3 osteoblasts 1 TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 6 55.48 antagonist 6 5.00 Pain 3 5.00 corticosteroid 2 5.00 metalloproteinase 2 5.00 colic 2 5.00 chemokine 2 5.00 Kinase C 2 5.00

Disease Link Frequency Relevance Heat Cancer 66 100.00 Osteoporosis 117 98.84 Osteolysis 16 97.60 Apoptosis 21 97.28 Metastasis 92 93.84 Hypercalcemia 23 91.24 Lung Cancer 4 77.12 Prostate Cancer 17 76.28 Breast Cancer 12 65.40 Disease 9 5.00

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Event

Anatomy

Negation

Speculation

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Disease term

However, blocking the OPG/RANK/RANKL pathway with RANK-Fc had no effect on tumor cells in nonosseous sites; the decrease in tumor burden following inhibition of the tumor-mediated osteolysis is an indirect effect secondary to interruption of the vicious cycle of osteolytic metastasis [43-45].

Negative_regulation (blocking) of Negative_regulation (decrease) of OPG associated with cancer, osteolysis and metastasis

1) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.59 Pain Relevance 0.03

In addition, osteoprotegerin expression is also decreased in osteoblasts and stromal cells in the presence of glucocorticoids.12 Osteoprotegerin plays a counterregulatory role in the effects of RANK-L, and down-regulation of osteoprotegerin also enhances osteoclastogenesis and decreases rates of osteoclast apoptosis.12

Negative_regulation (down) of Negative_regulation (regulation) of osteoprotegerin in stromal cells associated with apoptosis

2) Confidence 0.19 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.55 Pain Relevance 0

In addition, osteoprotegerin expression is also decreased in osteoblasts and stromal cells in the presence of glucocorticoids.12 Osteoprotegerin plays a counterregulatory role in the effects of RANK-L, and down-regulation of osteoprotegerin also enhances osteoclastogenesis and decreases rates of osteoclast apoptosis.12

Negative_regulation (down) of in osteoblasts Negative_regulation (regulation) of osteoprotegerin in stromal cells associated with apoptosis

3) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.55 Pain Relevance 0

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