INT210608

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.31
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TNFSF11) extracellular space (TNFSF11) extracellular region (TNFSF11)
plasma membrane (TNFSF11) intracellular (TNFSF11) response to stress (TNFSF11)
Anatomy Link Frequency
osteoclast 2
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 73.08 Quite High
cva 3 9.92 Low Low
antagonist 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 93 99.62 Very High Very High Very High
Osteoporosis 66 98.56 Very High Very High Very High
Prostate Cancer 17 93.88 High High
Osteolysis 16 86.64 High High
Hypercalcemia 21 83.88 Quite High
Breast Cancer 26 83.00 Quite High
Immunotherapy Of Cancer 8 81.88 Quite High
Reprotox - General 2 5 78.04 Quite High
Osteoporotic Fractures 4 77.92 Quite High
Lymphatic System Cancer 1 76.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A prior study in our laboratory using a mouse intratibial injection model of metastasis demonstrated that blocking the RANK-RANKL interaction by RANK-Fc (a recombinant soluble fusion protein consisting of extracellular domain of RANK coupled with the Fc domain of human IgG) limits the formation of osteolytic bone lesions [44].
Negative_regulation (blocking) of RANKL Binding (interaction) of associated with metastasis
1) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.33 Pain Relevance 0.04
Specifically, it enhances the osteoblastic production of osteoprotegerin, which has anti-osteoclastic properties because of its ability to bind to rankl and subsequently to block the rankl/rank interaction required for osteoclast recruitment and activation 59,60.
Negative_regulation (block) of rankl Binding (interaction) of in osteoclast associated with osteoporosis
2) Confidence 0.18 Published 2008 Journal Current Oncology Section Body Doc Link PMC2216420 Disease Relevance 0.99 Pain Relevance 0

General Comments

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