INT21067

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Context Info
Confidence 0.60
First Reported 1981
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 2.00
Pain Relevance 5.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
brain 4
outflow 2
pituitary 2
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 30 100.00 Very High Very High Very High
opiate 13 100.00 Very High Very High Very High
Endogenous opioid 12 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Clonidine 17 98.72 Very High Very High Very High
Dopamine 1 98.28 Very High Very High Very High
Pain 3 98.08 Very High Very High Very High
agonist 3 97.32 Very High Very High Very High
Opioid 4 91.40 High High
antagonist 4 91.24 High High
Disease Link Frequency Relevance Heat
Weight Gain 15 100.00 Very High Very High Very High
Hypothyroidism 2 98.76 Very High Very High Very High
Pain 2 98.08 Very High Very High Very High
Galactorrhea 6 95.80 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 95.64 Very High Very High Very High
Aggression 1 92.96 High High
Prolactinoma 2 92.92 High High
Body Weight 2 90.32 High High
Nociception 1 87.84 High High
Drug Induced Neurotoxicity 2 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Influence of stage of the estrous cycle on endogenous opioid modulation of luteinizing hormone, prolactin, and cortisol secretion in the gilt.
Regulation (Influence) of Regulation (modulation) of prolactin associated with narcan and endogenous opioid
1) Confidence 0.60 Published 1986 Journal Biol. Reprod. Section Title Doc Link 3828431 Disease Relevance 0.09 Pain Relevance 0.51
For efficacy we particularly sought information on response and/or remission, and for harm, information on weight gain, extrapyramidal symptoms, and changes in prolactin, glucose and lipid levels.
Regulation (information) of Regulation (changes) of prolactin associated with weight gain
2) Confidence 0.44 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2020469 Disease Relevance 0.15 Pain Relevance 0
The authors studied the influence of a therapeutic single dose of Li on the response of human growth hormone (HGH) prolactin (PRL) and thyrotropin (TSH) to clonidine (C), an alpha adrenergic agonist which stimulates the turn over of PIP2. 3.
Regulation (influence) of Regulation (response) of prolactin associated with agonist and clonidine
3) Confidence 0.42 Published 1990 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 2163062 Disease Relevance 0 Pain Relevance 0.27
The effect of naloxone on PRL and TSH response to TRH was studied in 8 normal men.
Regulation (effect) of Regulation (response) of PRL associated with narcan
4) Confidence 0.41 Published 1989 Journal Minerva Endocrinol. Section Abstract Doc Link 2503692 Disease Relevance 0 Pain Relevance 0.41
The role of opiate peptides in the control of prolactin in the puerperium, and TSH in primary hypothyroidism.
Regulation (role) of Regulation (control) of prolactin associated with hypothyroidism, narcan and opiate
5) Confidence 0.41 Published 1982 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 7074980 Disease Relevance 0.29 Pain Relevance 0.50
We investigated the participation by endogenous opioid peptides in the control of prolactin and gonadotropin secretion in 5 normal men and 6 normal women, and in 4 men and 5 women with persisting hyperprolactinemia following transsphenoidal pituitary microsurgery for prolactinomas.
Spec (investigated) Regulation (participation) of Regulation (control) of prolactin in pituitary associated with galactorrhea, prolactinoma and endogenous opioid
6) Confidence 0.39 Published 1981 Journal J. Endocrinol. Invest. Section Abstract Doc Link 7240669 Disease Relevance 0.32 Pain Relevance 0.37
Role of opiates in the physiological control of prolactin in man.
Regulation (Role) of Regulation (control) of prolactin associated with enkephalin and opiate
7) Confidence 0.27 Published 1983 Journal Acta Eur. Fertil. Section Title Doc Link 6326452 Disease Relevance 0.28 Pain Relevance 0.58
We conclude that alpha adrenoreceptor mechanisms are of major importance while opiate receptor mechanisms are of relatively minor importance in modulating the effects of glucoprivation on sympathetic outflow and hPP, GH, and PRL levels.
Regulation (importance) of Regulation (modulating) of PRL in outflow associated with opiate
8) Confidence 0.25 Published 1985 Journal Metab. Clin. Exp. Section Abstract Doc Link 3982277 Disease Relevance 0 Pain Relevance 0.67
Although they resembled controls in their prolactin response to L-tryptophan and their response to ischemic pain, MDMA users had lower scores on personality measures of impulsivity (p = .004) and indirect hostility (p = .009).
Regulation (controls) of Regulation (response) of prolactin associated with pain and attention deficit hyperactivity disorder
9) Confidence 0.24 Published 1994 Journal Neuropsychopharmacology Section Abstract Doc Link 7517677 Disease Relevance 0.71 Pain Relevance 0.30
Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic alpha 2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive alpha 2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man.
Regulation (role) of Regulation (regulation) of prolactin in brain associated with opiate and clonidine
10) Confidence 0.22 Published 1984 Journal Psychiatry Res Section Abstract Doc Link 6097932 Disease Relevance 0 Pain Relevance 0.63
Since clonidine's neuroendocrine effects are reportedly due to the activation of postsynaptic alpha 2-adrenoceptors, it appears that (1) continuous opiate use does not lead to the development of hypersensitive alpha 2-adrenergic receptors involved in neuroendocrine mechanisms and (2) brain norepinephrine does not play a role in the regulation of tonic prolactin, gonadotropin, and thyrotropin secretion in man.
Neg (not) Regulation (play) of Regulation (regulation) of prolactin in brain associated with opiate and clonidine
11) Confidence 0.22 Published 1984 Journal Psychiatry Res Section Abstract Doc Link 6097932 Disease Relevance 0 Pain Relevance 0.63
Moreover, the regulation of prolactin is probably under the control of endorphins interfering via dopamine (PIF).
Regulation (under) of Regulation (regulation) of prolactin associated with dopamine
12) Confidence 0.19 Published 1989 Journal Obstet Gynecol Surv Section Abstract Doc Link 2677858 Disease Relevance 0.15 Pain Relevance 0.43

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