INT210693

Context Info Confidence 0.46 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.30 Pain Relevance 1.77

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)

Slc12a2 (Mus musculus)

Pain Link Frequency Relevance Heat allodynia 80 99.32 GABAergic 19 98.66 c fibre 3 98.48 gABA 101 98.44 dorsal root ganglion 7 90.00 Inflammatory stimuli 2 86.40 antagonist 7 81.72 fibrosis 2 77.60 qutenza 32 75.44 Dopamine 34 72.00

Disease Link Frequency Relevance Heat Neuropathic Pain 83 99.32 Targeted Disruption 21 90.32 Ganglion Cysts 7 90.00 INFLAMMATION 15 86.40 Peripheral Arterial Disease 4 82.80 Cystic Fibrosis 2 78.16 Oligohydramnios 1 60.04 Cyst 1 50.16 Hyperalgesia 17 22.48 Pressure And Volume Under Development 13 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We and others have proposed that GABAergic mechanisms may explain allodynia in inflamed conditions such that NKCC1 activity increases leading to a large depolarization in C-fibers, causing spiking, in response to A?

Positive_regulation (increases) of Gene_expression (activity) of NKCC1 associated with c fibre, allodynia and gabaergic

1) Confidence 0.46 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.90 Pain Relevance 1.32

The NKCC1 cotransporter responds to relative changes in ion concentrations (see Methods), and as [Na+]o and [Cl?]

Positive_regulation (cotransporter) of Gene_expression (cotransporter) of NKCC1

2) Confidence 0.26 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0

o during stimulation (compared to [9],[13] whereas mc3 and mc5 associated with H3 and H5 (NBC only and NBC+NKCC1, respectively) predict an increase in [Cl?]

Positive_regulation (whereas) of Gene_expression (respectively) of NKCC1

3) Confidence 0.26 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0

-cotransporter (NKCC1) which sets up a Cl?

Positive_regulation (cotransporter) of Gene_expression (cotransporter) of NKCC1

4) Confidence 0.11 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2927192 Disease Relevance 0 Pain Relevance 0.38

cotransporter (NKCC), which mediates Cl?

Positive_regulation (cotransporter) of Gene_expression (cotransporter) of NKCC

5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994757 Disease Relevance 0.40 Pain Relevance 0.07

General Comments

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