INT210693

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.30
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)
Slc12a2 (Mus musculus)
Pain Link Frequency Relevance Heat
allodynia 80 99.32 Very High Very High Very High
GABAergic 19 98.66 Very High Very High Very High
c fibre 3 98.48 Very High Very High Very High
gABA 101 98.44 Very High Very High Very High
dorsal root ganglion 7 90.00 High High
Inflammatory stimuli 2 86.40 High High
antagonist 7 81.72 Quite High
fibrosis 2 77.60 Quite High
qutenza 32 75.44 Quite High
Dopamine 34 72.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 83 99.32 Very High Very High Very High
Targeted Disruption 21 90.32 High High
Ganglion Cysts 7 90.00 High High
INFLAMMATION 15 86.40 High High
Peripheral Arterial Disease 4 82.80 Quite High
Cystic Fibrosis 2 78.16 Quite High
Oligohydramnios 1 60.04 Quite High
Cyst 1 50.16 Quite High
Hyperalgesia 17 22.48 Low Low
Pressure And Volume Under Development 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We and others have proposed that GABAergic mechanisms may explain allodynia in inflamed conditions such that NKCC1 activity increases leading to a large depolarization in C-fibers, causing spiking, in response to A?
Positive_regulation (increases) of Gene_expression (activity) of NKCC1 associated with c fibre, allodynia and gabaergic
1) Confidence 0.46 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.90 Pain Relevance 1.32
The NKCC1 cotransporter responds to relative changes in ion concentrations (see Methods), and as [Na+]o and [Cl?]
Positive_regulation (cotransporter) of Gene_expression (cotransporter) of NKCC1
2) Confidence 0.26 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
o during stimulation (compared to [9],[13] whereas mc3 and mc5 associated with H3 and H5 (NBC only and NBC+NKCC1, respectively) predict an increase in [Cl?]
Positive_regulation (whereas) of Gene_expression (respectively) of NKCC1
3) Confidence 0.26 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
-cotransporter (NKCC1) which sets up a Cl?
Positive_regulation (cotransporter) of Gene_expression (cotransporter) of NKCC1
4) Confidence 0.11 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2927192 Disease Relevance 0 Pain Relevance 0.38
cotransporter (NKCC), which mediates Cl?
Positive_regulation (cotransporter) of Gene_expression (cotransporter) of NKCC
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994757 Disease Relevance 0.40 Pain Relevance 0.07

General Comments

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