INT210696

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.97
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv1, Slc12a2) plasma membrane (Trpv1, Slc12a2) transmembrane transport (Trpv1, Slc12a2)
cytosol (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
spinal 2
Trpv1 (Mus musculus)
Slc12a2 (Mus musculus)
Pain Link Frequency Relevance Heat
allodynia 160 99.50 Very High Very High Very High
Inflammation 26 99.30 Very High Very High Very High
Thermal hyperalgesia 2 96.64 Very High Very High Very High
Dorsal horn 14 96.28 Very High Very High Very High
dorsal root ganglion 14 93.92 High High
Dopamine 68 91.44 High High
agonist 28 91.24 High High
Pain 28 88.16 High High
qutenza 64 87.16 High High
antagonist 10 77.92 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 162 99.50 Very High Very High Very High
Nociception 6 99.48 Very High Very High Very High
INFLAMMATION 30 99.30 Very High Very High Very High
Hyperalgesia 34 96.64 Very High Very High Very High
Ganglion Cysts 14 93.92 High High
Pain 18 79.60 Quite High
Targeted Disruption 6 13.08 Low Low
Peripheral Arterial Disease 8 5.00 Very Low Very Low Very Low
Dyspepsia 4 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings further implicate NKCC1 in inflammatory allodynia and suggest that spinal TRPV1 receptors might be involved in regulating NKCC1 activity in nociceptive primary afferents.


TRPV1 Regulation (regulating) of NKCC1 in spinal associated with nociception, allodynia and inflammation
1) Confidence 0.25 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.87 Pain Relevance 1.18
The majority of these neurons also express NKCC1 [29], hence, we reasoned that spinal TRPV1 receptors might be involved in regulating NKCC1 activity.
TRPV1 Regulation (regulating) of NKCC1 in spinal
2) Confidence 0.25 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 1.09 Pain Relevance 1.40

General Comments

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