INT210709

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 9.21
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
macrophages 4
monocytes 3
brains 1
neutrophils 1
microglia 1
Itgam (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 278 95.28 Very High Very High Very High
cerebral cortex 12 94.84 High High
antagonist 82 89.80 High High
Inflammatory response 24 89.76 High High
cytokine 154 86.08 High High
metalloproteinase 47 83.24 Quite High
agonist 34 77.24 Quite High
substance P 4 67.20 Quite High
Hippocampus 5 54.76 Quite High
ischemia 64 50.00 Quite Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 5 99.80 Very High Very High Very High
Adhesions 50 99.44 Very High Very High Very High
Asthma 40 98.84 Very High Very High Very High
Disease 195 98.48 Very High Very High Very High
Pulmonary Disease 429 98.40 Very High Very High Very High
Middle Cerebral Artery Infarction 88 96.48 Very High Very High Very High
INFLAMMATION 293 95.28 Very High Very High Very High
Infection 88 79.28 Quite High
Bacteremia 13 77.04 Quite High
Stroke 62 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of rh-IL-10 in control siRNA transfected animals reduced the bacterial load, whereas it had no effect on CR3 knocked down animals.
Neg (no) Regulation (effect) of CR3
1) Confidence 0.28 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.21 Pain Relevance 0.04
MMP-9 seems to be derived from infiltrating granulocytes, monocytes or macrophages, since MMP-9 and CD11b immunoreactivity appear to co-localize.
Regulation (immunoreactivity) of CD11b in macrophages
2) Confidence 0.26 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1929071 Disease Relevance 0.29 Pain Relevance 0.22
The Mac-1 (CD11b/CD18) integrin might be a further interesting target because this adhesion molecule is overexpressed on neutrophils from COPD patients (Noguera et al 1998), and it is also present on the surface of monocytes and macrophages.
Spec (might) Regulation (target) of CD11b/CD18 in monocytes associated with pulmonary disease and adhesions
3) Confidence 0.26 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.19 Pain Relevance 0.23
Figure 1C) were expressed by activated CD11b+ microglia and infiltrating CD11b+ macrophages/granulocytes.


Regulation (infiltrating) of CD11b in microglia
4) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0 Pain Relevance 0
CD11b immunoreactivity in the brains of TLR4m and TLR4w non-AD mice was unremarkable (data not shown).
Regulation (immunoreactivity) of CD11b in brains associated with disease
5) Confidence 0.19 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 0.60 Pain Relevance 0.31
However, neutrophils harvested from the surface of EPA-treated endothelial cells did not shed l-selectin or up-regulate CD11b.
Neg (not) Regulation (regulate) of CD11b in neutrophils
6) Confidence 0.18 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0 Pain Relevance 0.07
Staining with CD11b, which stains invading macrophages/monocytes as well as activated microglia, revealed that there was no significant alteration of CD11b-positive cells in the ischemic hemisphere of CD59a-ko mice (section 1: 301 ± 4 [60 min MCAO], 252 ± 61 [30 min MCAO]; section 2: 410 ± 123 [60 min MCAO], 365 ± 96 [30 min MCAO]); section 3: 600 ± 342 [60 min MCAO], 188 ± 52 [30 min MCAO]) when compared to that of wild-type mice (section 1: 337 ± 110 [60 min MCAO], 162 ± 102 [30 min MCAO]; section 2: 530 ± 197 [60 min MCAO], 437 ± 34 [30 min MCAO]; section 3: 575 ± 286 [60 min MCAO], 259 ± 102 [30 min MCAO]) in both models (48 h after 60 min MCAO; 72 h after 30 min MCAO) (data not shown).


Regulation (alteration) of CD11b in monocytes associated with middle cerebral artery infarction
7) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 1.60 Pain Relevance 0.09
The Mac-1 (CD11b/CD18) integrin might be a further interesting target because this adhesion molecule is overexpressed on neutrophils from COPD patients (Noguera et al 1998), and it is also present on the surface of monocytes and macrophages.
Spec (might) Regulation (target) of CD11b/CD18 in macrophages associated with pulmonary disease and adhesions
8) Confidence 0.09 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.19 Pain Relevance 0.23
100, Becton Dickinson) were used as control antibodies for CD11b and PAC-1, respectively.


Regulation (control) of CD11b associated with heart rate under development
9) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.18 Pain Relevance 0.03
Staining with CD11b, which stains invading macrophages/monocytes as well as activated microglia, revealed that there was no significant alteration of CD11b-positive cells in the ischemic hemisphere of CD59a-ko mice (section 1: 301 ± 4 [60 min MCAO], 252 ± 61 [30 min MCAO]; section 2: 410 ± 123 [60 min MCAO], 365 ± 96 [30 min MCAO]); section 3: 600 ± 342 [60 min MCAO], 188 ± 52 [30 min MCAO]) when compared to that of wild-type mice (section 1: 337 ± 110 [60 min MCAO], 162 ± 102 [30 min MCAO]; section 2: 530 ± 197 [60 min MCAO], 437 ± 34 [30 min MCAO]; section 3: 575 ± 286 [60 min MCAO], 259 ± 102 [30 min MCAO]) in both models (48 h after 60 min MCAO; 72 h after 30 min MCAO) (data not shown).


Regulation (alteration) of CD11b in macrophages associated with middle cerebral artery infarction
10) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 1.60 Pain Relevance 0.09
The Mac-1 (CD11b/CD18) integrin might be a further interesting target because this adhesion molecule is overexpressed on neutrophils from COPD patients (Noguera et al 1998), and it is also present on the surface of monocytes and macrophages.
Spec (might) Regulation (target) of Mac-1 in monocytes associated with pulmonary disease and adhesions
11) Confidence 0.01 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.19 Pain Relevance 0.23
The Mac-1 (CD11b/CD18) integrin might be a further interesting target because this adhesion molecule is overexpressed on neutrophils from COPD patients (Noguera et al 1998), and it is also present on the surface of monocytes and macrophages.
Spec (might) Regulation (target) of Mac-1 in macrophages associated with pulmonary disease and adhesions
12) Confidence 0.00 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.19 Pain Relevance 0.23

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