INT21076

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.48
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tear 1
Muc5ac (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 12 99.98 Very High Very High Very High
antagonist 2 99.64 Very High Very High Very High
aspirin 6 99.26 Very High Very High Very High
Morphine 5 98.96 Very High Very High Very High
Antinociceptive 8 95.08 Very High Very High Very High
Analgesic 2 90.08 High High
tolerance 4 88.92 High High
Inflammation 59 86.16 High High
Kappa opioid receptor 3 85.16 High High
tail-flick 1 75.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 73 99.86 Very High Very High Very High
Teratoma 15 98.82 Very High Very High Very High
Disorders Of The Lacrimal System 37 98.40 Very High Very High Very High
Cyst 11 97.20 Very High Very High Very High
Metaplasia 24 95.36 Very High Very High Very High
Stress 4 84.68 Quite High
Cancer 12 81.44 Quite High
Eye Disease 11 69.28 Quite High
Asthma 2 67.68 Quite High
Infection 39 66.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rewarding effect of MGM-9 was blocked by a mu antagonist and enhanced by a kappa antagonist.
Negative_regulation (blocked) of MGM-9 associated with antagonist
1) Confidence 0.42 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18550129 Disease Relevance 0 Pain Relevance 1.32
Figure 2 shows the relative copy numbers of Muc4, Muc5b and Muc5ac normalized with the 18s for mice fed with the three diets.
Negative_regulation (numbers) of Muc5ac
2) Confidence 0.41 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0 Pain Relevance 0
Northern blot analysis using 3 mice showed an increase of the Muc5ac messenger with a peak at day 4 followed by a decrease of Muc5ac RNA [41].
Negative_regulation (decrease) of Muc5ac
3) Confidence 0.40 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.23 Pain Relevance 0
The characterisation of mucin in a mature ovarian teratoma occurring in an eight year old patient

Introduction: The presence of MUC5AC (M1 antigen) and MUC6 have previously been found in ovarian mucinous cyst.

Negative_regulation (presence) of MUC5AC associated with teratoma and cyst
4) Confidence 0.35 Published 2007 Journal International Journal of Medical Sciences Section Title Doc Link PMC1852400 Disease Relevance 0.45 Pain Relevance 0
Nonsteroidal anti-inflammatory drugs inhibit gastric peroxidase activity.
Negative_regulation (inhibit) of gastric peroxidase associated with inflammation and cinod
5) Confidence 0.23 Published 1990 Journal Biochim. Biophys. Acta Section Title Doc Link 2163678 Disease Relevance 0.19 Pain Relevance 0.46
This damage causes a remarkable decrease in tear-binding mucins (MUC5AC, MUC19) [11,12], reduced goblet cell density (GCD) [13], and an increase in cornified envelop precursors such as small proline rich proteins (SPRRs) [14,15].
Negative_regulation (decrease) of MUC5AC in tear
6) Confidence 0.23 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 1.29 Pain Relevance 0.25
NSAIDs inhibit gastric peroxidase activity more effectively at acid pH (pH 5.2) than at neutral pH.
Negative_regulation (inhibit) of gastric peroxidase associated with cinod
7) Confidence 0.17 Published 1990 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2163678 Disease Relevance 0.15 Pain Relevance 0.37
Purified rat gastric peroxidase activity was inhibited 75% with 0.15 mM indomethacin showing half-maximal inhibition at 0.04 mM.
Negative_regulation (inhibited) of gastric peroxidase
8) Confidence 0.15 Published 1990 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2163678 Disease Relevance 0.16 Pain Relevance 0.38

General Comments

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