INT210766

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.15
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Igf1r) kinase activity (Igf1r)
Anatomy Link Frequency
pituitary 2
brain 1
Igf1r (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 51 79.60 Quite High
tolerance 16 75.48 Quite High
Inflammation 27 52.48 Quite High
dexamethasone 94 50.00 Quite Low
Central nervous system 21 45.44 Quite Low
anesthesia 6 27.68 Quite Low
cytokine 13 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 63 96.32 Very High Very High Very High
Death 21 93.96 High High
Apoptosis 9 93.68 High High
Gastrointestinal Stromal Tumor 67 91.48 High High
Lifespan 139 85.12 High High
Targeted Disruption 35 79.20 Quite High
Impaired Glucose Tolerance 20 75.48 Quite High
Cancer 140 72.24 Quite High
Hyperplasia 4 64.08 Quite High
Pituitary Cancer 3 63.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, in this model the IGF-1R gene is knocked out in the hypothalamus but not in the pituitary (Figure 3A).
Neg (not) Gene_expression (knocked) of IGF-1R gene in pituitary
1) Confidence 0.65 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0 Pain Relevance 0.11
Antibodies used were anti-IGF-1R ?
Gene_expression (anti) of IGF-1R
2) Confidence 0.65 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.05 Pain Relevance 0.11
Reportedly, long-lived female mice heterozygote for the IGF-1 receptor (Igf1r+/?)
Gene_expression (/) of Igf1r
3) Confidence 0.62 Published 2011 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC3001304 Disease Relevance 0.25 Pain Relevance 0.04
Reportedly, long-lived female mice heterozygote for the IGF-1 receptor (Igf1r+/?)
Gene_expression (/) of IGF-1 receptor
4) Confidence 0.62 Published 2011 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC3001304 Disease Relevance 0.25 Pain Relevance 0.04
We showed that diminishing IGF-1R expression in the brain selectively reduced somatotropic function.
Gene_expression (expression) of IGF-1R in brain
5) Confidence 0.58 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.97 Pain Relevance 0.03
IGF1R is amplified and over-expressed in the majority of GISTs that lack c-KIT or PDGFR?
Gene_expression (expressed) of IGF1R
6) Confidence 0.40 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.55 Pain Relevance 0
Generally, GC decrease IGF-I, GH receptor and IGF receptor 1 expression and also abrogate the release of GH from the pituitary [20,28,29].
Gene_expression (expression) of IGF receptor 1 in pituitary
7) Confidence 0.12 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.08 Pain Relevance 0

General Comments

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