INT210774

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.05
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
chondrocytes 1
Igh-Dex (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 282 100.00 Very High Very High Very High
metalloproteinase 6 20.72 Low Low
cytokine 27 18.48 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 9 51.48 Quite High
Hypertrophy 12 24.28 Low Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low
Osteoporosis 9 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Leukemia 6 5.00 Very Low Very Low Very Low
Natriuresis 3 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary monolayer chondrocytes were treated with 10-7 M dexamethasone (DEX) or the DMSO control (vehicle) diluted in fresh media supplemented with 0.25 mM ascorbic acid (Sigma) and 1 mM ?
Regulation (control) of DEX in chondrocytes associated with dexamethasone
1) Confidence 0.03 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.13
Approximately 70% of significantly changed probe sets exhibited upregulation in response to DEX treatment.
Regulation (response) of DEX associated with dexamethasone
2) Confidence 0.03 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.05 Pain Relevance 0.16
Also, the overall effect of DEX treatment on gene expression was modest, which may have reduced the significance of biologically relevant genes because their signal intensities were close to background levels.
Regulation (effect) of DEX associated with dexamethasone
3) Confidence 0.03 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.20

General Comments

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