INT21078

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Context Info
Confidence 0.70
First Reported 1982
Last Reported 2004
Negated 1
Speculated 2
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 0.78
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pxk) nucleus (Pxk) molecular_function (Pxk)
cellular_component (Pxk) biological_process (Pxk) cytoplasm (Pxk)
Anatomy Link Frequency
brain 2
CNT 1
DCT 1
skeletal muscle 1
myotubes 1
Pxk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 5 99.76 Very High Very High Very High
noradrenaline 15 99.56 Very High Very High Very High
agonist 7 96.40 Very High Very High Very High
Clonidine 4 95.84 Very High Very High Very High
tetrodotoxin 3 95.04 Very High Very High Very High
Action potential 1 92.32 High High
Serotonin 1 89.36 High High
Enkephalin 2 84.72 Quite High
Migraine 4 75.00 Quite High
Central nervous system 1 68.80 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 1 84.40 Quite High
Autolysis 1 80.36 Quite High
Cancer 1 77.48 Quite High
Migraine With Aura 4 75.00 Quite High
Diuresis 2 75.00 Quite High
Postmortem Changes 1 75.00 Quite High
Epilepsy 1 58.12 Quite High
Disease 1 57.36 Quite High
Hyperplasia 4 5.00 Very Low Very Low Very Low
Hypertrophy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it seems likely that in rat brain homogenate the increase of Na,K-ATPase activity and inhibition of endogenous lipid peroxidation by noradrenaline are related.
Positive_regulation (increase) of Na,K-ATPase in brain associated with noradrenaline
1) Confidence 0.70 Published 1982 Journal Biochem. Pharmacol. Section Abstract Doc Link 6127081 Disease Relevance 0 Pain Relevance 0.37
The results demonstrate that veratridine-induced increase in Na influx both depolarizes cultured myotubes and increases the activity of the Na-K pump, which repolarizes Em to levels higher than control.
Positive_regulation (increases) of Na-K in myotubes
2) Confidence 0.69 Published 1990 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 2163752 Disease Relevance 0 Pain Relevance 0.09
No increase of Na,K-ATPase activity by noradrenaline could be detected after preincubation of the homogenate for 5 min at 37 degrees.
Neg (No) Positive_regulation (increase) of Na,K-ATPase associated with noradrenaline
3) Confidence 0.61 Published 1982 Journal Biochem. Pharmacol. Section Abstract Doc Link 6127081 Disease Relevance 0 Pain Relevance 0.38
The mechanism of the inhibitory effect of ouabain on vasoconstrictors was not resolved but may operate via stimulation of Na-K ATPase.
Positive_regulation (stimulation) of Na-K ATPase
4) Confidence 0.51 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2410710 Disease Relevance 0 Pain Relevance 0.18
Drugs which enhanced Na,K-ATPase activity--noradrenaline, adrenaline and oxymethazoline--were found to inhibit endogenous membrane lipid peroxidation.
Positive_regulation (enhanced) of Na,K-ATPase associated with noradrenaline
5) Confidence 0.47 Published 1982 Journal Biochem. Pharmacol. Section Abstract Doc Link 6127081 Disease Relevance 0 Pain Relevance 0.31
Faster K+ deocclusion of the mutant via the E2(K) + ATP --> E1.ATP + K+ partial reaction is evidenced in (i) a marked increase (300%) in K+ stimulation of Na-ATPase at micromolar ATP, (ii) a 4-fold decrease in KATP, and (iii) only a modest increase (approximately 3-fold) in I50 for vanadate, which was used as a probe of the steady state E1/E2 conformational equilibrium.
Positive_regulation (stimulation) of Na-ATPase
6) Confidence 0.35 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15308625 Disease Relevance 0.31 Pain Relevance 0.23
The findings demonstrate that activity of electrogenic Na,K-ATPase is increased by T4-treatment and that this effect is primarily responsible for the elevated Em in T4-treated cells.
Positive_regulation (increased) of Na,K-ATPase
7) Confidence 0.33 Published 1984 Journal Brain Res. Section Abstract Doc Link 6697244 Disease Relevance 0 Pain Relevance 0.14
Since, however, the distribution space for rubidium was significantly increased in chronic torasemide animals, rubidium uptake, and hence Na,K-ATPase activity, must have increased in proportion to cell volume in DCT and CNT cells, but more than proportionately in principal cells.
Spec (must) Positive_regulation (increased) of Na,K-ATPase in DCT
8) Confidence 0.27 Published 1997 Journal Kidney Int. Section Abstract Doc Link 8995715 Disease Relevance 0.07 Pain Relevance 0
Na,K-ATPase and low-affinity Ca-ATPase activities were also stable in brains kept at 25 degrees C for up to 72 h.
Positive_regulation (stable) of Na,K-ATPase in brains
9) Confidence 0.19 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3029332 Disease Relevance 0.24 Pain Relevance 0.11
Since, however, the distribution space for rubidium was significantly increased in chronic torasemide animals, rubidium uptake, and hence Na,K-ATPase activity, must have increased in proportion to cell volume in DCT and CNT cells, but more than proportionately in principal cells.
Spec (must) Positive_regulation (increased) of Na,K-ATPase in CNT
10) Confidence 0.09 Published 1997 Journal Kidney Int. Section Abstract Doc Link 8995715 Disease Relevance 0.07 Pain Relevance 0
Role of protein kinase C in insulin activation of the Na-K pump in cultured skeletal muscle.
Positive_regulation (activation) of Na-K in skeletal muscle associated with kinase c
11) Confidence 0.04 Published 1994 Journal Am. J. Physiol. Section Title Doc Link 8166238 Disease Relevance 0.08 Pain Relevance 0.22

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