INT2108

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Context Info
Confidence 0.77
First Reported 1977
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.70
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
extracellular region (Mif) nucleus (Mif) cytoplasm (Mif)
Anatomy Link Frequency
Macrophage 2
lymphocytes 1
pituitary 1
Mif (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 5 100.00 Very High Very High Very High
corticosteroid 1 99.36 Very High Very High Very High
Inflammation 42 97.00 Very High Very High Very High
cytokine 17 96.44 Very High Very High Very High
anesthesia 3 75.00 Quite High
imagery 27 66.00 Quite High
addiction 1 25.60 Quite Low
fibrosis 4 17.84 Low Low
rheumatoid arthritis 2 5.76 Low Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 49 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 5 100.00 Very High Very High Very High
Injury 8 98.98 Very High Very High Very High
Hypersensitivity 3 90.12 High High
Bacterial Infection 2 85.68 High High
Autosomal Dominant Polycystic Kidney 111 83.32 Quite High
Cancer 82 82.40 Quite High
Albuminuria 4 69.68 Quite High
Disease 51 56.64 Quite High
Necrosis 4 51.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The discovery that MIF was secreted from corticotrophic pituitary cells led to its classification as a hormone as well as a cytokine.
Localization (secreted) of MIF in pituitary associated with cytokine
1) Confidence 0.77 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 0.72 Pain Relevance 0.22
In vivo stimulation with endotoxin promotes secretion of MIF from pools of stored protein within the cell allowing immediate amplification of the inflammatory response.
Localization (secretion) of MIF associated with inflammatory response
2) Confidence 0.68 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 0.95 Pain Relevance 0.21
The AA. have evaluated the effects of anaesthesia and surgical trauma on the ability of lymphocytes from 10 patients to release Leukocyte Inhibiting Factor (LIF) after stimulation with phytohaemoagglutinin (PHA).
Localization (release) of Leukocyte Inhibiting Factor in lymphocytes associated with injury
3) Confidence 0.06 Published 1977 Journal G Batteriol Virol Immunol Section Abstract Doc Link 350684 Disease Relevance 0.17 Pain Relevance 0.07
Macrophage migration inhibitory factor (MIF) is a central mediator of inflammatory response and acute lung injury that is secreted in response to corticosteroids.
Localization (secreted) of migration inhibitory factor in Macrophage associated with corticosteroid, inflammatory response and adult respiratory distress syndrome
4) Confidence 0.05 Published 2004 Journal Shock Section Abstract Doc Link 15545824 Disease Relevance 0.20 Pain Relevance 0.14
Urinary macrophage migration inhibitory factor (MIF) and monocyte chemotatic protein 1 (MCP-1) were chosen as markers of inflammation.
Localization (macrophage) of migration inhibitory factor in macrophage associated with inflammation
5) Confidence 0.04 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.66 Pain Relevance 0.08

General Comments

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