INT210805

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (IHH) extracellular space (IHH) extracellular region (IHH)
plasma membrane (IHH) cell-cell signaling (IHH)
Anatomy Link Frequency
chondrocyte 1
IHH (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 99.56 Very High Very High Very High
dexamethasone 94 53.44 Quite High
Pain 10 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteochondroma 47 97.44 Very High Very High Very High
Malignant Neoplastic Disease 16 95.64 Very High Very High Very High
Multiple Hereditary Exostoses 45 72.00 Quite High
Chondrosarcoma 14 35.84 Quite Low
Bone Cancer 3 33.28 Quite Low
Cancer 11 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Probes for Indian hedgehog (Ihh), Tissue inhibitor of matrix metalloproteinase 4 (Timp4), Cyclin-dependent kinase inhibitor 1C (Cdkn1c, p57), Integrin beta like 1 protein (Itgbl1), GC receptor (Nr3c1), Integrin beta 1 (Itgb1) and Kruppel-like factor 15 (Klf15) were assayed using the TaqMan® gene expression assays in accordance with the manufacturers directions.
Negative_regulation (inhibitor) of Indian hedgehog associated with metalloproteinase
1) Confidence 0.42 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.08
PTHLH signalling, which is downstream of IHH and is responsible for chondrocyte proliferation, is absent in osteochondroma, while being upregulated upon malignant transformation of osteochondroma [59,60].
Negative_regulation (downstream) of IHH in chondrocyte associated with malignant neoplastic disease and osteochondroma
2) Confidence 0.35 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2276198 Disease Relevance 0.74 Pain Relevance 0

General Comments

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