INT210835

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc4r) plasma membrane (Mc4r) signal transducer activity (Mc4r)
Mc4r (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 13 99.40 Very High Very High Very High
mu opioid receptor 1 95.84 Very High Very High Very High
Morphine 1 91.88 High High
Analgesic 1 91.52 High High
Immobilon 1 87.48 High High
opioid receptor 1 83.16 Quite High
Potency 5 68.72 Quite High
5HT 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 13 55.24 Quite High
Cancer 1 39.52 Quite Low
Body Weight 5 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low
Overweight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It will be interesting to further explore the molecular basis of agonist-selective internalization at MC4R and to identify potential differences in phosphorylation by GRKs or arrestin binding that underlie this observation.
Phosphorylation (phosphorylation) of MC4R associated with agonist
1) Confidence 0.51 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0.06 Pain Relevance 0.52

General Comments

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