INT210858

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPM3) cytoskeleton (TPM3) molecular_function (TPM3)
cytoplasm (TPM3)
Anatomy Link Frequency
TM3 2
TPM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 97.40 Very High Very High Very High
agonist 58 96.28 Very High Very High Very High
Potency 15 95.12 Very High Very High Very High
antagonist 12 83.92 Quite High
gABA 20 51.48 Quite High
Bioavailability 1 42.08 Quite Low
cocaine 7 5.00 Very Low Very Low Very Low
addiction 7 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 13 37.28 Quite Low
Disease 2 17.68 Low Low
Anxiety Disorder 13 5.00 Very Low Very Low Very Low
Drug Dependence 5 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Spasticity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All mutants with increased basal activity were close to the EL1/TM2 or EL1/TM3 boundaries.
Gene_expression (boundaries) of TM3 in TM3
1) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0 Pain Relevance 0.13
Both types of modulators were found to bind in a cavity within the HD, contacting residues of TM3, TM5 TM6 and TM7, therefore at a site clearly distinct from the glutamate binding site located in the VFT.
Gene_expression (residues) of TM3 in TM3 associated with glutamate
2) Confidence 0.13 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.26

General Comments

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