INT210859

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.46
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (EPB41) plasma membrane (EPB41) nucleus (EPB41)
protein complex (EPB41) cytoplasm (EPB41)
Anatomy Link Frequency
band 3
blood 1
TM3 1
spine 1
EPB41 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 13 89.04 High High
antagonist 2 83.92 Quite High
cytokine 8 83.24 Quite High
Inflammation 7 82.84 Quite High
Potency 5 77.40 Quite High
Pain 1 38.00 Quite Low
cerebral cortex 9 27.40 Quite Low
tetrodotoxin 30 5.00 Very Low Very Low Very Low
Glutamate receptor 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 6 97.20 Very High Very High Very High
Adhesions 20 95.88 Very High Very High Very High
Metabolic Syndrome 52 93.52 High High
Cleft Palate 6 87.60 High High
INFLAMMATION 6 82.84 Quite High
Stress 1 81.80 Quite High
Diabetes Mellitus 10 76.92 Quite High
Hypertension 7 76.52 Quite High
Disorder Of Lipid Metabolism 6 64.64 Quite High
Aging 3 57.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because CASK and protein 4.1 are widely expressed in different tissues, SUMOylation of CASK may also regulate the interaction between CASK and protein 4.1 in nonneuronal cells.
Gene_expression (expressed) of protein 4.1
1) Confidence 0.75 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.16 Pain Relevance 0
Because the protein 4.1–binding site covers only around 10 amino acid residues, it was inconvenient to simply express the protein 4.1–binding site alone to interrupt the interaction between endogenous CASK and protein 4.1.
Gene_expression (express) of protein 4.1
2) Confidence 0.75 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
These results suggested that the PDZ domain and protein 4.1–binding sites of CASK have to be present in the same molecule to perform their functions in spine morphology.
Gene_expression (present) of protein 4.1 in spine
3) Confidence 0.65 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
All mutants with increased basal activity were close to the EL1/TM2 or EL1/TM3 boundaries.
Gene_expression (boundaries) of EL1 in TM3
4) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0 Pain Relevance 0.13
To identify cortical loci expressing intra-regional gamma-band synchronization time-locked to button presses indicating perceptual switching, the Multiple Source Beamformer implemented in BESA was applied to data from each subject using a standard realistic head model.
Gene_expression (expressing) of gamma-band in band
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702101 Disease Relevance 0 Pain Relevance 0
PLVs were computed from the differences of the instantaneous phases for pairs of time series from the reconstructed gamma-band sources, for example, sources j and k, at each point in time, t, across the N available epochs [81]:
Gene_expression (sources) of gamma-band in band
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702101 Disease Relevance 0 Pain Relevance 0
Time windows of interest were selected by averaging the time-frequency data across participants and across a subset of electrodes that encompassed the fronto-parietal regions where theta-modulated gamma-band activity was expressed most clearly (F1, F3, F5, F2, F4, F6, FC1, FC3, FC5, FC2, FC4, FC6, C1, C3, C5, C2, C4, C6, CP1, CP3, CP5, CP2, CP4, CP6, P1, P3, P5, P2, P4, P6).
Gene_expression (expressed) of gamma-band in band
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702101 Disease Relevance 0 Pain Relevance 0
We not only analyzed mTOR but also its downstream effectors p70S6K and 4EPB1 which stimulate anabolic pathway and other fundamental biochemical pathways such as the production of adhesion molecules, replace damaged cells and cell survival (including blood and endothelial cells with consequent regulation of blood coagulation).
Spec (analyzed) Gene_expression (effectors) of 4EPB1 in blood associated with adhesions
8) Confidence 0.00 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 1.30 Pain Relevance 0.08

General Comments

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