INT21087

Context Info Confidence 0.32 First Reported 1990 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 0.31 Pain Relevance 0.58

cytosol (Ppp3ca) mitochondrion (Ppp3ca) nucleus (Ppp3ca) enzyme binding (Ppp3ca) response to stress (Ppp3ca) cytoplasm (Ppp3ca)

Anatomy Link Frequency heart 2 ileum 1 Ppp3ca (Mus musculus)

Pain Link Frequency Relevance Heat methadone 3 99.92 Morphine 3 96.00 MU agonist 2 76.56 agonist 11 71.24 antagonist 1 33.24 Enkephalin 2 25.00 fibrosis 12 5.00 anesthesia 3 5.00 isoflurane 3 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 27 97.94 Hyperplasia 15 86.68 Coronary Heart Disease 3 49.56 Body Weight 6 30.68 Embryonic Lethality 3 30.00 Arrhythmia Under Development 39 5.00 Sudden Death 12 5.00 Fibrosis 9 5.00 Death 9 5.00 Infection 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Taken together with the insensitivity of methadone to beta-CNA blockade in the guinea-pig ileum, but not mouse vas deferens, the difference in the affinity of normorphine in these tissues may suggest the possibility of differences in local milieu of mu receptors or of mu receptor subtypes in the two tissues.

Negative_regulation (blockade) of beta-CNA in ileum associated with methadone

1) Confidence 0.32 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2163849 Disease Relevance 0 Pain Relevance 0.58

At 3 weeks of age, CnB1fl/flcTnT-Cre mice showed a 90% reduction in CnB and CnA protein in the heart when compared with untargeted mice.

Negative_regulation (reduction) of CnA in heart

2) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.13 Pain Relevance 0

The Nkx2.5-Cre knock-in allele produced a very robust deletion of CnB1 from the heart, which resulted in a nearly complete loss of CnB and CnA protein from the heart as assayed at birth.

Negative_regulation (loss) of CnA in heart associated with targeted disruption

3) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.18 Pain Relevance 0

Mice with single disruption of CnA?

Negative_regulation (disruption) of CnA

4) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0 Pain Relevance 0

General Comments

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