INT21087

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Context Info
Confidence 0.32
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.31
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp3ca) mitochondrion (Ppp3ca) nucleus (Ppp3ca)
enzyme binding (Ppp3ca) response to stress (Ppp3ca) cytoplasm (Ppp3ca)
Anatomy Link Frequency
heart 2
ileum 1
Ppp3ca (Mus musculus)
Pain Link Frequency Relevance Heat
methadone 3 99.92 Very High Very High Very High
Morphine 3 96.00 Very High Very High Very High
MU agonist 2 76.56 Quite High
agonist 11 71.24 Quite High
antagonist 1 33.24 Quite Low
Enkephalin 2 25.00 Low Low
fibrosis 12 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 27 97.94 Very High Very High Very High
Hyperplasia 15 86.68 High High
Coronary Heart Disease 3 49.56 Quite Low
Body Weight 6 30.68 Quite Low
Embryonic Lethality 3 30.00 Quite Low
Arrhythmia Under Development 39 5.00 Very Low Very Low Very Low
Sudden Death 12 5.00 Very Low Very Low Very Low
Fibrosis 9 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low
Infection 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together with the insensitivity of methadone to beta-CNA blockade in the guinea-pig ileum, but not mouse vas deferens, the difference in the affinity of normorphine in these tissues may suggest the possibility of differences in local milieu of mu receptors or of mu receptor subtypes in the two tissues.
Negative_regulation (blockade) of beta-CNA in ileum associated with methadone
1) Confidence 0.32 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2163849 Disease Relevance 0 Pain Relevance 0.58
At 3 weeks of age, CnB1fl/flcTnT-Cre mice showed a 90% reduction in CnB and CnA protein in the heart when compared with untargeted mice.
Negative_regulation (reduction) of CnA in heart
2) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.13 Pain Relevance 0
The Nkx2.5-Cre knock-in allele produced a very robust deletion of CnB1 from the heart, which resulted in a nearly complete loss of CnB and CnA protein from the heart as assayed at birth.
Negative_regulation (loss) of CnA in heart associated with targeted disruption
3) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.18 Pain Relevance 0
Mice with single disruption of CnA?
Negative_regulation (disruption) of CnA
4) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0 Pain Relevance 0

General Comments

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