INT210934

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tlr4, Ccl2) extracellular space (Ccl2) signal transduction (Tlr4)
extracellular region (Ccl2) plasma membrane (Tlr4) intracellular (Tlr4)
Anatomy Link Frequency
cardiac myocytes 2
Tlr4 (Mus musculus)
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 2 100.00 Very High Very High Very High
Inflammation 5 99.08 Very High Very High Very High
cytokine 36 95.52 Very High Very High Very High
ischemia 18 78.88 Quite High
Inflammatory response 6 47.44 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 99.08 Very High Very High Very High
Myocardial Infarction 5 93.20 High High
Apoptosis 4 91.72 High High
Coronary Heart Disease 6 86.56 High High
Cv Unclassified Under Development 12 78.88 Quite High
Sprains And Strains 3 65.60 Quite High
Stress 3 59.60 Quite High
Ischemic Heart Disease 6 58.36 Quite High
Injury 6 9.16 Low Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has to be considered that the absence of TLR4, not only reduces infarct size, but also other regulatory proteins, such as the chemokine monocyte chemoattractant protein (MCP)-1, which may prolong inflammation and delay replacement of injured cardiac myocytes [30].
Neg (12850) Gene_expression (absence) of TLR4 in cardiac myocytes Negative_regulation (reduces) of MCP associated with chemokine and inflammation
1) Confidence 0.47 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1933437 Disease Relevance 0.69 Pain Relevance 0.54

General Comments

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