INT210968

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.98
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
central nervous system 1
neuromuscular junction 1


Pain Term Frequency Confidence Heat
agonist 20 99.68 Very High Very High Very High
Central nervous system 19 99.28 Very High Very High Very High
Cannabinoid 13 98.66 Very High Very High Very High
depression 49 98.44 Very High Very High Very High
GABAergic 15 97.88 Very High Very High Very High
Neuropathic pain 14 96.80 Very High Very High Very High
Analgesic 5 95.28 Very High Very High Very High
Pain 8 93.36 High High
Endocannabinoid 49 91.76 High High
Cannabinoid receptor 3 91.36 High High
Disease Term Frequency Confidence Heat
Depression 49 98.44 Very High Very High Very High
Neuropathic Pain 64 96.80 Very High Very High Very High
Pain 9 93.36 High High
Graves' Ophthalmopathy 1 72.76 Quite High
Targeted Disruption 4 62.80 Quite High
Nervous System Injury 8 17.20 Low Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Obsessive-compulsive Disorder 1 5.00 Very Low Very Low Very Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these data show that the inhibitory effects of the CB agonist are due to the activation of CB1 receptors.
Positive_regulation (activation) of CB1 associated with agonist
1) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.16 Pain Relevance 0.55
However, activation of CB1 receptors in the central nervous system (CNS) is also associated with adverse psychoactivity [2].
Positive_regulation (activation) of CB1 in central nervous system associated with central nervous system
2) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2719614 Disease Relevance 0.57 Pain Relevance 1.04
Unlike in the lizard neuromuscular junction, cannabinoids could depress transmission on their own but, in the presence of the cholinergic agonist, the NO–cGMP and cannabinoid pathways converged, apparently at the presynaptic location (where CB1 receptors and NO-evoked cGMP accumulation were located) to elicit the transient depression of GABAergic transmission.
Neg (NO) Positive_regulation (accumulation) of CB1 in neuromuscular junction associated with depression, gabaergic, cannabinoid and agonist
3) Confidence 0.45 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.25 Pain Relevance 0.61

General Comments

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