INT210972

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
dendrites 4
spines 2
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 11 93.96 High High
antagonist 13 89.76 High High
Hippocampus 15 85.04 High High
depression 39 69.84 Quite High
Pyramidal cell 31 65.04 Quite High
Glutamate 9 53.20 Quite High
Endocannabinoid 11 50.00 Quite Low
Action potential 22 37.60 Quite Low
agonist 10 5.48 Low Low
Calcium channel 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 39 69.84 Quite High
Targeted Disruption 11 60.52 Quite High
Anxiety Disorder 29 50.00 Quite Low
Shock 15 5.00 Very Low Very Low Very Low
Schizophrenia 8 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the subcellular localization of the mGluRs mediating the medium ADP, DHPG was applied locally, by pressure application from a large patch pipette, to either the perisomatic region or the apical dendrites (see Materials and Methods for details).
Positive_regulation (mediating) of Spec (determine) Localization (localization) of mGluRs in dendrites
1) Confidence 0.06 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.13
Thus, our data demonstrate that postsynaptic spines in the PFC contain the two key proteins necessary to translate glutamatergic signals (mGluR5) into eCB (DGL-?)
Positive_regulation (necessary) of Localization (translate) of mGluR5 in spines
2) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.18 Pain Relevance 0.26
Vesl-1S expression triggers the translocation of mGluR5 to both the dendrites and axons of cultured cerebellar granule cells [42].
Positive_regulation (triggers) of Localization (translocation) of mGluR5 in dendrites
3) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.06 Pain Relevance 0.09

General Comments

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