INT210975

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.30
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cfp)
Anatomy Link Frequency
PFC 3
hippocampus 3
hypothalamus 1
Cfp (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 270 100.00 Very High Very High Very High
Hippocampus 56 99.92 Very High Very High Very High
fluoxetine 40 99.72 Very High Very High Very High
cannabis 34 99.14 Very High Very High Very High
amygdala 4 98.72 Very High Very High Very High
Cannabinoid 66 98.44 Very High Very High Very High
antidepressant 264 95.00 High High
depression 408 86.92 High High
Lasting pain 2 82.36 Quite High
antagonist 38 62.84 Quite High
Disease Link Frequency Relevance Heat
Poisoning 434 100.00 Very High Very High Very High
Disease 4 99.80 Very High Very High Very High
Schizophrenia 34 99.76 Very High Very High Very High
Shock 16 99.42 Very High Very High Very High
Congenital Anomalies 3 95.00 High High
Cognitive Disorder 7 93.84 High High
Brain Disease 2 90.60 High High
Autism 2 87.24 High High
Depression 444 86.92 High High
Stroke 2 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deregulations of the eCB system in the prefrontal cortex (PFC) may also participate to this disease [8].
Regulation (Deregulations) of PFC in cortex associated with disease
1) Confidence 0.24 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 1.29 Pain Relevance 0.28
Colocalization of CFP and NF-L immunoreactivities was determined from confocal images of the GCL from five retinal wholemounts (Table 1).
Regulation (immunoreactivities) of CFP
2) Confidence 0.23 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.40 Pain Relevance 0
Colocalization of CFP and NeuN immunoreactivities was determined from confocal images of the GCL from five retinal wholemounts (Table 1).
Regulation (immunoreactivities) of CFP
3) Confidence 0.23 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.33 Pain Relevance 0
Cannabinoids have deleterious effects on prefrontal cortex (PFC)-mediated functions and multiple evidences link the endogenous cannabinoid (endocannabinoid) system, cannabis use and schizophrenia, a disease in which PFC functions are altered.
Regulation (altered) of PFC in PFC associated with endocannabinoid, cannabis, cannabinoid, disease and schizophrenia
4) Confidence 0.15 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1933592 Disease Relevance 0.20 Pain Relevance 0.39
On the contrary, it has been reported that chronic fluoxetine causes an up-regulation of CB1 receptors in the Prefrontal cortex (PFC), [78,79], chronic DMI up-regulates CB1 receptors in the hypothalamus and hippocampus [78,79], tranylcypromine (a MAOI) decreases the levels of anandamide in the PFC, hippocampus and hypothalamus, and increases CB1 receptor binding in PFC and the hippocampus, but not in the hypothalamus [78,79].
Regulation (regulation) of PFC in PFC associated with hippocampus and fluoxetine
5) Confidence 0.09 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.30 Pain Relevance 0.91
Organizing the different levels at which we may identify risk factors influencing CFP can contribute to facilitate this systematic approach (Table 3).

4.4.2.

Regulation (influencing) of CFP associated with poisoning
6) Confidence 0.07 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.88 Pain Relevance 0
Extensive reviews on CFP provide comprehensive analyses regarding the importance of CFP and the different factors that influence it [2,3,16–24].
Spec (analyses) Regulation (importance) of CFP associated with poisoning
7) Confidence 0.07 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.76 Pain Relevance 0
A single administration of ECS produces a reduction in the affinity of CB1 receptors in the PFC, hippocampus, hypothalamus and amigdala, reduces anandamide levels in the PFC and hippocampus, and FAAH activity in the PFC.
Regulation (affinity) of PFC in hippocampus associated with shock and hippocampus
8) Confidence 0.06 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.56 Pain Relevance 0.47
For the first time, a new animal model has been established in this study which shows white matter alterations in PFC, CP and the hippocampus, in addition to the abnormal behaviors mimicking the heterogeneity of schizophrenia symptoms.
Regulation (alterations) of PFC in hippocampus associated with hippocampus and schizophrenia
9) Confidence 0.06 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.44 Pain Relevance 0.09
A recent study published by Hill et al [81] demonstrated that chronic administration of DMI does not modify endocannabinoid levels in the PFC, hippocampus, hypothalamus, or amygdala, but increases CB1 receptor density in the hippocampus and hypothalamus.
Neg (not) Regulation (modify) of PFC in hypothalamus associated with endocannabinoid, hippocampus and amygdala
10) Confidence 0.04 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.07 Pain Relevance 0.89
A recent study published by Hill et al [81] demonstrated that chronic administration of DMI does not modify endocannabinoid levels in the PFC, hippocampus, hypothalamus, or amygdala, but increases CB1 receptor density in the hippocampus and hypothalamus.
Neg (not) Regulation (modify) of PFC in hippocampus associated with endocannabinoid, hippocampus and amygdala
11) Confidence 0.01 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.07 Pain Relevance 0.89

General Comments

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