INT210982

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) extracellular region (Cfp) aging (Cnr1)
plasma membrane (Cnr1) signal transducer activity (Cnr1)
Anatomy Link Frequency
blood 1
PFC 1
Cnr1 (Mus musculus)
Cfp (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 13 99.64 Very High Very High Very High
cannabis 10 94.48 High High
fluoxetine 10 94.34 High High
Endocannabinoid 73 89.68 High High
Cannabinoid 20 84.76 Quite High
antidepressant 66 68.36 Quite High
antagonist 13 65.92 Quite High
depression 120 55.68 Quite High
Lasting pain 1 51.12 Quite High
amygdala 1 45.60 Quite Low
Disease Link Frequency Relevance Heat
Schizophrenia 7 98.16 Very High Very High Very High
Psychosis 6 96.00 Very High Very High Very High
Disease 2 72.72 Quite High
Cognitive Disorder 1 62.60 Quite High
Stress 15 60.72 Quite High
Brain Disease 1 59.36 Quite High
Autism 1 56.00 Quite High
Depression 129 55.68 Quite High
Stroke 1 53.56 Quite High
Glioma 1 52.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, increased density of binding at CB1R in the PFC of schizophrenics has been demonstrated [13], [14] while other studies have shown increased anandamide levels in the CSF or blood of schizophrenics [15]–[17].
CB1R Binding (binding) of PFC in blood
1) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 1.15 Pain Relevance 0.20
On the contrary, it has been reported that chronic fluoxetine causes an up-regulation of CB1 receptors in the Prefrontal cortex (PFC), [78,79], chronic DMI up-regulates CB1 receptors in the hypothalamus and hippocampus [78,79], tranylcypromine (a MAOI) decreases the levels of anandamide in the PFC, hippocampus and hypothalamus, and increases CB1 receptor binding in PFC and the hippocampus, but not in the hypothalamus [78,79].
CB1 Binding (binding) of PFC in PFC associated with hippocampus and fluoxetine
2) Confidence 0.06 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.12 Pain Relevance 0.99

General Comments

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