INT210983

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.81
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Calb1) signal transduction (Cnr1) aging (Cnr1)
plasma membrane (Cnr1) nucleus (Calb1) intracellular (Calb1)
Anatomy Link Frequency
synapses 1
Calb1 (Mus musculus)
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 38 99.52 Very High Very High Very High
Nucleus accumbens 3 98.18 Very High Very High Very High
antagonist 8 92.28 High High
dopamine receptor 1 75.88 Quite High
Pyramidal cell 13 68.28 Quite High
Endocannabinoid 11 50.00 Quite Low
agonist 8 5.00 Very Low Very Low Very Low
Cannabinoid 7 5.00 Very Low Very Low Very Low
cannabis 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 38 99.52 Very High Very High Very High
Schizophrenia 7 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Brain Disease 1 5.00 Very Low Very Low Very Low
Anaerobic Bacterial Infections 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, as previously described at the PrPFC to nucleus accumbens synapses [28], activation of mGluR5 is necessary to induce eCB-LTD via a yet unidentified eCB that activates presynaptic CB1R.
eCB Positive_regulation (activates) of CB1R in synapses associated with nucleus accumbens and depression
1) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.81 Pain Relevance 0.68

General Comments

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