INT211011

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 1.95
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
testis 4
embryos 2
plasma 1
external 1
PKDREJ (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 30 97.84 Very High Very High Very High
Mechanotransduction 15 53.16 Quite High
member 8 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 150 90.00 High High
Polycystic Kidney Disease 120 75.00 Quite High
Renal Failure 15 66.24 Quite High
Cyst 15 64.72 Quite High
Stress 15 58.72 Quite High
Autosomal Dominant Polycystic Kidney 45 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-Q-PCR was used to determine the expression of SpREJ genes in six adult tissues (Figure 3).
Gene_expression (expression) of SpREJ
1) Confidence 0.46 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
Expression of SpREJ genes in adult sea urchin tissues
Gene_expression (Expression) of SpREJ
2) Confidence 0.46 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
Expression of SpREJ genes in developing embryos
Gene_expression (Expression) of SpREJ in embryos
3) Confidence 0.46 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
SpREJ6 is the only SpREJ with relatively low expression levels in testis.
Gene_expression (expression) of SpREJ in testis
4) Confidence 0.40 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
This study is the first to show the developmental expression of SpREJ in sea urchin embryos.
Gene_expression (expression) of SpREJ in embryos
5) Confidence 0.40 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
Expression of SpREJ genes in adult sea urchin tissues
Gene_expression (genes) of SpREJ
6) Confidence 0.40 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
RT-Q-PCR analysis of adult tissue expression of SpREJ transcripts indicates that, relative to the other SpREJs, SpREJ1 and 6 have dramatically high tissue-specific expression patterns (Figure 3).
Gene_expression (expression) of SpREJ
7) Confidence 0.36 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
To generalize, with the exception of SpREJ1 in testis and SpREJ6 in muscle/test, most SpREJ genes are expressed in easily measurable levels in these adult tissues.
Gene_expression (expressed) of SpREJ in testis
8) Confidence 0.36 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0.22 Pain Relevance 0
Adult tissues show tissue-specific patterns of SpREJ expression.


Gene_expression (expression) of SpREJ
9) Confidence 0.36 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC1934368 Disease Relevance 0.30 Pain Relevance 0
The REJ domains of these two proteins are 82% identical.
Gene_expression (domains) of REJ
10) Confidence 0.35 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0.06 Pain Relevance 0
Experimental work suggests that PKD repeats and REJ domains might have the same function in allowing the force mediated, reversible unfolding of these domains, permitting extension and retraction of the external portions of these enormous proteins as they link to the surfaces of other cells [35].
Gene_expression (repeats) of REJ in external
11) Confidence 0.35 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0.03
The intronless hPKDREJ is only expressed in mammalian testis [19] and associates with several TRP channel proteins and modulates G-protein signaling [20].
Gene_expression (expressed) of hPKDREJ in testis associated with trp channel
12) Confidence 0.31 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0.43 Pain Relevance 0.09
SpREJ6 is the only SpREJ that is weakly expressed in testis.
Gene_expression (expressed) of SpREJ in testis
13) Confidence 0.31 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0.19 Pain Relevance 0
Each adult tissue shows a tissue-specific pattern of expression of the 10 SpREJ transcripts.


Gene_expression (expression) of SpREJ
14) Confidence 0.31 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0.36 Pain Relevance 0
Mammalian PKDREJ, like sea urchin SpREJ3, is found only in the plasma membrane covering the sperm acrosomal vesicle [21].
Gene_expression (found) of PKDREJ in plasma
15) Confidence 0.31 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0.39 Pain Relevance 0.09

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