INT211029

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.54
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr2c) plasma membrane (Htr2c) nucleus (Htr2c)
cytoplasm (Htr2c) signal transducer activity (Htr2c)
Htr2c (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 30 85.48 High High
Serotonin 9 82.08 Quite High
fluoxetine 6 78.08 Quite High
Pyramidal cell 9 40.88 Quite Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Neuronal excitability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 159 99.40 Very High Very High Very High
Obesity 3 94.20 High High
Attention Deficit Hyperactivity Disorder 6 93.28 High High
Sprains And Strains 27 92.68 High High
Weight Gain 6 90.04 High High
Epilepsy 63 62.40 Quite High
Disease 15 60.00 Quite High
Inborn Genetic Diseases 3 58.56 Quite High
Absence Epilepsy 15 52.76 Quite High
Targeted Disruption 21 28.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, because Htr2c expression is reduced only modestly (?
Negative_regulation (reduced) of Gene_expression (expression) of Htr2c
1) Confidence 0.56 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.64 Pain Relevance 0.07
Frankel, unpublished data), suggests that down-regulating Htr2c receptor expression is not sufficient to account for the handling-induced seizures.
Negative_regulation (regulating) of Gene_expression (expression) of Htr2c associated with convulsion
2) Confidence 0.41 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 1.01 Pain Relevance 0.06
This suggests that factors in addition to reduced expression of Htr2c contribute to seizure threshold in Brunol4Ff/+ mice.
Negative_regulation (reduced) of Gene_expression (expression) of Htr2c associated with convulsion
3) Confidence 0.41 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.89 Pain Relevance 0.12

General Comments

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