INT211030

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.62
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf4) mRNA processing (Celf4) RNA binding (Celf4)
nucleus (Celf4) cytoplasm (Celf4)
Anatomy Link Frequency
neuronal 1
brain 1
Atlas 1
Celf4 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal excitability 3 98.96 Very High Very High Very High
Hippocampus 30 96.08 Very High Very High Very High
Serotonin 9 89.92 High High
Pyramidal cell 9 76.44 Quite High
cerebral cortex 6 65.72 Quite High
fluoxetine 6 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 159 91.32 High High
Neurodegenerative Disease 3 85.32 High High
Obesity 3 61.96 Quite High
Attention Deficit Hyperactivity Disorder 6 61.04 Quite High
Epilepsy 63 50.00 Quite Low
Targeted Disruption 21 47.20 Quite Low
Absence Epilepsy 15 43.00 Quite Low
Disease 15 27.76 Quite Low
Inborn Genetic Diseases 3 26.32 Quite Low
Sprains And Strains 27 14.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we cannot ignore other genes misregulated in Brunol4 mutants, some with unknown function (Table S1), since many also expressed selectively within the hippocampus in B6 mice (Allen Brain Atlas [32]).
Regulation (misregulated) of Brunol4 in Atlas associated with hippocampus
1) Confidence 0.45 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.27 Pain Relevance 0.12
Thus, in the absence or reduction of BRUNOL4, these molecules become dysregulated, leading to imbalance in neuronal excitability.
Regulation (dysregulated) of BRUNOL4 in neuronal associated with neuronal excitability
2) Confidence 0.39 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.26 Pain Relevance 0.23
Expression analysis of the neighboring genes with potential brain function did not reveal difference between Ff/Ff homozygous mutants and normal controls (unpublished data), suggesting that Brunol4 is the only brain-expressed gene affected by the transgene insertion.
Regulation (affected) of Brunol4 in brain
3) Confidence 0.27 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.09 Pain Relevance 0

General Comments

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