INT211033

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.64
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf4) mRNA processing (Celf4) RNA binding (Celf4)
nucleus (Celf4) cytoplasm (Celf4)
Anatomy Link Frequency
brain 1
Celf4 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 6 80.16 Quite High
Serotonin 9 78.12 Quite High
cerebral cortex 6 53.20 Quite High
Hippocampus 30 40.64 Quite Low
Pyramidal cell 9 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Neuronal excitability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 63 99.24 Very High Very High Very High
Absence Epilepsy 15 98.64 Very High Very High Very High
Inborn Genetic Diseases 3 97.52 Very High Very High Very High
Disease 15 95.64 Very High Very High Very High
Convulsion 159 95.36 Very High Very High Very High
Sprains And Strains 27 92.28 High High
Targeted Disruption 21 88.88 High High
Weight Gain 6 32.36 Quite Low
Attention Deficit Hyperactivity Disorder 6 31.24 Quite Low
Obesity 3 22.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prospect of a defective RNA-binding protein such as BRUNOL4 causing a complex seizure disorder suggests a way in which a single gene defect can mimic a complex genetic disease, by impairing the function of multiple molecules simultaneously.
BRUNOL4 Binding (binding) of associated with epilepsy, inborn genetic diseases and disease
1) Confidence 0.37 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.99 Pain Relevance 0
Here, we report on the causal association between Brunol4, encoding a brain-specific RNA-binding protein, and the seizure disorder of frequent-flyer mouse mutants.
Brunol4 Binding (association) of in brain associated with epilepsy
2) Confidence 0.36 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.66 Pain Relevance 0.12
to the insertion site and p2 containing the region between BRUNOL4?
BRUNOL4 Binding (region) of
3) Confidence 0.32 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0 Pain Relevance 0.03

General Comments

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