INT21105

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Context Info
Confidence 0.82
First Reported 1990
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 0.83
Pain Relevance 19.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
thalamus 4
cerebellum 3
brain 2
striatum 1
nucleus 1
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 122 100.00 Very High Very High Very High
Enkephalin 34 100.00 Very High Very High Very High
mu opioid receptor 29 100.00 Very High Very High Very High
agonist 71 99.84 Very High Very High Very High
Thalamus 72 99.68 Very High Very High Very High
narcan 30 99.68 Very High Very High Very High
Morphine 84 99.58 Very High Very High Very High
Opioid 17 99.08 Very High Very High Very High
tolerance 21 98.12 Very High Very High Very High
Analgesic 4 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 4 96.28 Very High Very High Very High
Nociception 2 75.56 Quite High
Pain 4 75.00 Quite High
Drug Dependence 1 69.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extent of mu receptor phosphorylation identified in the thalamus, striatum and cerebellum is consistent with the previous studies of mu receptor distribution.
Phosphorylation (phosphorylation) of mu receptor in thalamus associated with thalamus
1) Confidence 0.82 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.49
Mu receptor phosphorylation in the thalamus was much greater than the striatum, while no phosphorylation of the mu receptor in the cerebellum was detected, even with DAMGO treatment.
Phosphorylation (phosphorylation) of Mu receptor in cerebellum associated with thalamus
2) Confidence 0.82 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.39
Furthermore, we correlated the change of mu receptor phosphorylation with the desensitization of the mu receptor function, specifically, inhibition of adenylyl cyclase activity in the thalamus of morphine-tolerant rats.
Phosphorylation (phosphorylation) of mu receptor in thalamus associated with thalamus and morphine
3) Confidence 0.82 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.73
We found that in the thalamus of rats chronically treated with morphine, the enhancement of mu receptor phosphorylation in basal and DAMGO-treated samples paralleled the desensitization of DAMGO-mediated inhibition of adenylyl cyclase.
Phosphorylation (phosphorylation) of mu receptor in thalamus associated with thalamus and morphine
4) Confidence 0.82 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.75
Mu receptor phosphorylation in the thalamus was much greater than the striatum, while no phosphorylation of the mu receptor in the cerebellum was detected, even with DAMGO treatment.
Neg (no) Phosphorylation (phosphorylation) of mu receptor in cerebellum associated with thalamus
5) Confidence 0.82 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.38
Our results suggest that mu receptor phosphorylation in vivo may play an important role in the modulation of mu receptor function following both acute exposure to morphine and during the development of morphine tolerance.
Phosphorylation (phosphorylation) of mu receptor associated with tolerance and morphine
6) Confidence 0.82 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.76
Agonist-induced mu opioid receptor phosphorylation and functional desensitization in rat thalamus.
Phosphorylation (phosphorylation) of mu opioid receptor in thalamus associated with mu opioid receptor, agonist and thalamus
7) Confidence 0.82 Published 2001 Journal Brain Res. Section Title Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.44
The time course and dose-response studies demonstrated that mu receptor phosphorylation was a rapid event, exhibited a positive dose-dependent response, and was similar to that observed in the cloned mu receptor in CHO cells.
Phosphorylation (phosphorylation) of mu receptor
8) Confidence 0.82 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.56
The time course and dose-response studies demonstrated that mu receptor phosphorylation was a rapid event, exhibited a positive dose-dependent response, and was similar to that observed in the cloned mu receptor in CHO cells.
Phosphorylation (phosphorylation) of mu receptor
9) Confidence 0.81 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.59
Together, we identify CaMKII as a potential protein kinase, which by virtue of its colocalization with MOR1 may be in a position to phosphorylate the mu-opioid receptor and may thus contribute to the development of tolerance to opioid analgesics.
Phosphorylation (phosphorylate) of mu-opioid receptor associated with analgesic, tolerance, opioid receptor and opioid
10) Confidence 0.80 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11146127 Disease Relevance 0.22 Pain Relevance 1.03
We have recently identified the serine residues, Ser(261) and Ser(266), within the third intracellular loop as two consensus calcium/calmodulin-dependent protein kinase II (CaMKII) sites required for agonist-induced phosphorylation and desensitization of the mu-opioid receptor in HEK 293 cells.
Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist and opioid receptor
11) Confidence 0.80 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11146127 Disease Relevance 0.20 Pain Relevance 1.06
The effects of phosphorylation of a mu-opioid receptor on signal transduction to G-protein were studied.
Phosphorylation (phosphorylation) of mu-opioid receptor associated with opioid receptor
12) Confidence 0.74 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2164175 Disease Relevance 0 Pain Relevance 0.26
Phosphorylated mu-opioid receptor purified from rat brains lacks functional coupling with Gi1, a GTP-binding protein in reconstituted lipid vesicles.
Phosphorylation (Phosphorylated) of mu-opioid receptor in vesicles associated with enkephalin and opioid receptor
13) Confidence 0.74 Published 1990 Journal Neurosci. Lett. Section Title Doc Link 2164175 Disease Relevance 0 Pain Relevance 0.37
By metabolically labeling tissue slices from striatum and thalamus with [32P]orthophosphoric acid and immunoprecipitating the receptor with mu receptor-specific antiserum, we found that the endogenous mu receptor in the brain tissue did undergo phosphorylation.
Phosphorylation (phosphorylation) of mu receptor in brain associated with thalamus
14) Confidence 0.72 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.36
Palmitoylation of the rat mu opioid receptor.
Phosphorylation (Palmitoylation) of mu opioid receptor associated with mu opioid receptor
15) Confidence 0.71 Published 1998 Journal FEBS Lett. Section Title Doc Link 9877183 Disease Relevance 0 Pain Relevance 0.26
When the mu-opioid receptor was phosphorylated by cyclic AMP-dependent protein kinase prior to reconstitution with Gi1, the DAGO-stimulation was markedly reduced (20% increase at 1 mM DAGO).
Phosphorylation (phosphorylated) of mu-opioid receptor associated with opioid receptor
16) Confidence 0.65 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2164175 Disease Relevance 0 Pain Relevance 0.27
Mutation of Ser(355) and Thr(357) also greatly impaired DAMGO-induced mu-opioid receptor phosphorylation.
Phosphorylation (phosphorylation) of mu-opioid receptor associated with opioid receptor
17) Confidence 0.61 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12123746 Disease Relevance 0 Pain Relevance 0.70
There is no evidence that agonist-induced mu-opioid receptor phosphorylation changes in chronically morphine-treated animals, although receptor regulation appears to be altered.
Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist, opioid receptor and morphine
18) Confidence 0.43 Published 2005 Journal Neurosignals Section Abstract Doc Link 16772732 Disease Relevance 0.07 Pain Relevance 1.07
The extent of mu receptor phosphorylation identified in the thalamus, striatum and cerebellum is consistent with the previous studies of mu receptor distribution.
Phosphorylation (phosphorylation) of mu receptor in cerebellum associated with thalamus
19) Confidence 0.28 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.49
The extent of mu receptor phosphorylation identified in the thalamus, striatum and cerebellum is consistent with the previous studies of mu receptor distribution.
Phosphorylation (phosphorylation) of mu receptor in striatum associated with thalamus
20) Confidence 0.28 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.49

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