INT211054

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 4.53
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (AQP1) plasma membrane (AQP1) nucleus (AQP1)
transmembrane transport (AQP1) cytoplasm (AQP1)
Anatomy Link Frequency
plasma 1
neurons 1
ependymal cells 1
AQP1 1
astrocytes 1
AQP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Facet joint 1 97.12 Very High Very High Very High
cerebral cortex 2 96.00 Very High Very High Very High
Spinal cord 40 95.00 High High
Peripheral nervous system 25 93.72 High High
Central nervous system 35 89.48 High High
Neuropathic pain 10 88.56 High High
Pain 10 59.36 Quite High
Inflammation 12 42.12 Quite Low
Neurotransmitter 7 42.00 Quite Low
Inflammatory response 5 25.68 Quite Low
Disease Link Frequency Relevance Heat
Lewy Body Disease 3 99.40 Very High Very High Very High
Cancer 50 99.20 Very High Very High Very High
Creutzfeldt Jakob Disease 10 99.08 Very High Very High Very High
Hypoxia 5 98.78 Very High Very High Very High
Disease 98 98.08 Very High Very High Very High
Sclerosis 1 97.52 Very High Very High Very High
Frailty 12 95.00 High High
Pressure And Volume Under Development 40 93.24 High High
Cyst 5 91.24 High High
Neuropathic Pain 10 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 28 kDa protein, subsequently known as CHIP28 and re-named AQP1 for Aquaporin 1, was purified from red blood cells and renal proximal tubule membranes [3, 22] and then characterized as a water channel showing that Xenopus Laevis oocytes expressing AQP1 in their plasma membrane were far more susceptible to osmotic lysis than non-expressing oocytes [77].
Positive_regulation (named) of AQP1 in plasma
1) Confidence 0.33 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.07 Pain Relevance 0
AQP1 is up-regulated in choroids plexus tumours [55], which are associated with increased CSF production, against supporting a role for this isoform in CSF secretion.
Positive_regulation (up-regulated) of AQP1 in AQP1 associated with cancer
2) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.23 Pain Relevance 0.21
In particular, they reported that constant hypoxic conditions in chronically injured spinal cords persistently elevate AQP1 in neurons, ependymal cells, astrocytes, and sensory fibers and so may contribute to different pathological condition after spinal cord injury, such as neuronal/axonal swelling, over-production of CSF and formation of cysts, or excessive axonal sprouting underlying the development of neuropathic pain and autonomic dysreflexia [64].
Positive_regulation (elevate) of AQP1 in neurons associated with autonomic dysreflexia, pressure and volume under development, hypoxia, neuropathic pain, cyst and spinal cord
3) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.86 Pain Relevance 0.37
Significant increased expression levels of AQP1 and AQP4 were seen in CJD, but not in advanced AD and DLB cases.
Positive_regulation (increased) of AQP1 associated with creutzfeldt jakob disease, lewy body disease and disease
4) Confidence 0.27 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.55 Pain Relevance 0.05
In particular, they reported that constant hypoxic conditions in chronically injured spinal cords persistently elevate AQP1 in neurons, ependymal cells, astrocytes, and sensory fibers and so may contribute to different pathological condition after spinal cord injury, such as neuronal/axonal swelling, over-production of CSF and formation of cysts, or excessive axonal sprouting underlying the development of neuropathic pain and autonomic dysreflexia [64].
Positive_regulation (elevate) of AQP1 in ependymal cells associated with autonomic dysreflexia, pressure and volume under development, hypoxia, neuropathic pain, cyst and spinal cord
5) Confidence 0.11 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.86 Pain Relevance 0.37
In particular, they reported that constant hypoxic conditions in chronically injured spinal cords persistently elevate AQP1 in neurons, ependymal cells, astrocytes, and sensory fibers and so may contribute to different pathological condition after spinal cord injury, such as neuronal/axonal swelling, over-production of CSF and formation of cysts, or excessive axonal sprouting underlying the development of neuropathic pain and autonomic dysreflexia [64].
Positive_regulation (elevate) of AQP1 in astrocytes associated with autonomic dysreflexia, pressure and volume under development, hypoxia, neuropathic pain, cyst and spinal cord
6) Confidence 0.11 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.86 Pain Relevance 0.37
Urine NTx and BSAP remained suppressed with continuous alendronate, but increased by about 25% when treatment was discontinued although they remained below baseline for the 5 years of observation
Positive_regulation (increased) of Urine NTx in Urine
7) Confidence 0.01 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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