INT211055

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.85
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAX5) nucleus (PAX5) DNA binding (PAX5)
Anatomy Link Frequency
Urine 1
PAX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Facet joint 1 97.12 Very High Very High Very High
Osteoarthritis 171 77.84 Quite High
imagery 54 64.44 Quite High
Arthritis 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 11 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 42 98.42 Very High Very High Very High
Sclerosis 4 97.52 Very High Very High Very High
Osteoporosis 61 94.52 High High
Knee Osteoarthritis 144 77.84 Quite High
Frailty 5 72.52 Quite High
Disease 22 60.72 Quite High
Compression Fractures 3 59.72 Quite High
Helminth Infection 6 23.80 Low Low
Osteoarthritis 27 12.16 Low Low
Endometriosis (extended) 8 6.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the overall model (including age, sex, and BMI) predicting BMLs was statistically significant for each biomarker, neither Ln-BSAP or Ln-osteocalcin exhibited a statistically significant univariate association with BMLs, regardless of how BMLs were defined.
BSAP Binding (association) of associated with obesity
1) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.23 Pain Relevance 0.10
BSAP was measured using a monoclonal antibody that exhibits specificity for BSAP (Alkphase-B; Metra Biosystems, Mountain View, CA, USA), thus providing a quantitative measure of BSAP activity in serum as a measure of osteoblastic activity.
BSAP Binding (specificity) of associated with osteoporosis
2) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.29 Pain Relevance 0
Urine NTx and BSAP remained suppressed with continuous alendronate, but increased by about 25% when treatment was discontinued although they remained below baseline for the 5 years of observation
BSAP Binding (Urine NTx) of in Urine
3) Confidence 0.25 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.10 Pain Relevance 0.05
For Ln-BSAP, there was a modest nonsignificant association, with the odds of a BML being present increasing 1.4-fold per 1 standard deviation increase in the Ln-BSAP.
BSAP Binding (association) of
4) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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