INT21106

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Context Info
Confidence 0.61
First Reported 1990
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
thalamus 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 5 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
mu opioid receptor 3 100.00 Very High Very High Very High
Thalamus 6 95.36 Very High Very High Very High
Morphine 6 94.88 High High
MU agonist 1 85.20 High High
Kinase C 1 84.16 Quite High
narcan 2 70.48 Quite High
tolerance 2 60.08 Quite High
addiction 1 59.52 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we correlated the change of mu receptor phosphorylation with the desensitization of the mu receptor function, specifically, inhibition of adenylyl cyclase activity in the thalamus of morphine-tolerant rats.
Regulation (change) of Phosphorylation (phosphorylation) of mu receptor in thalamus associated with thalamus and morphine
1) Confidence 0.61 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.73
The effects of phosphorylation of a mu-opioid receptor on signal transduction to G-protein were studied.
Regulation (effects) of Phosphorylation (phosphorylation) of mu-opioid receptor associated with opioid receptor
2) Confidence 0.41 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2164175 Disease Relevance 0 Pain Relevance 0.26
Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+-dependent.
Regulation (dependent) of Phosphorylation (phosphorylation) of mu opioid receptor associated with agonist and mu opioid receptor
3) Confidence 0.01 Published 1996 Journal FEBS Lett. Section Title Doc Link 8654566 Disease Relevance 0 Pain Relevance 0.44

General Comments

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