INT211066

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.56
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMD) cytoskeleton (DMD) nucleus (DMD)
cytoplasm (DMD)
Anatomy Link Frequency
neck 2
liver 2
spine 2
DMD (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 24 73.44 Quite High
alcohol 8 48.80 Quite Low
backache 11 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 11 99.38 Very High Very High Very High
Osteogenesis Imperfecta 12 98.32 Very High Very High Very High
Cirrhosis 10 98.20 Very High Very High Very High
Osteoporosis 285 97.16 Very High Very High Very High
Hypercalcemia 70 92.32 High High
Renal Insufficiency 1 89.40 High High
Endometriosis (extended) 13 86.40 High High
Disease 15 81.56 Quite High
Hypophosphatemia 1 80.32 Quite High
Hypocalcemia 2 79.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTH stimulates both bone formation and resorption, leading to increased or decreased BMD, depending on the mode of administration.
Negative_regulation (decreased) of Positive_regulation (increased) of BMD
1) Confidence 0.16 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686344 Disease Relevance 0.65 Pain Relevance 0
Lumbar spine BMD increased by 2.8% and 5.0% in the 1 mg and 2 mg groups, respectively and decreased by 0.04% in the placebo group (Figure 5).
Negative_regulation (decreased) of Positive_regulation (increased) of BMD in spine
2) Confidence 0.11 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684081 Disease Relevance 0.22 Pain Relevance 0
The losses of the lumbar BMD in patients with liver cirrhosis and the metacarpal BMD in hemiplegic patients after stroke are prevented, and the lumbar BMD is possibly increased, preventing fragile fractures in adult patients with osteogenesis imperfecta type I.
Negative_regulation (preventing) of Spec (possibly) Positive_regulation (increased) of BMD in liver associated with cirrhosis, stroke and osteogenesis imperfecta
3) Confidence 0.07 Published 2005 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2815806 Disease Relevance 1.41 Pain Relevance 0.14
In contrast, the increase in BMD at the femoral neck in men treated with teriparatide was slower, only reaching significance at 18 months (2.9 ± 1.5%; p < 0.05).
Negative_regulation (slower) of Positive_regulation (increase) of BMD in neck
4) Confidence 0.04 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.28 Pain Relevance 0
This increase in BMD lead to a significant decreases in both vertebral fractures (65% and 69%) and nonvertebral fractures (53% and 54%) for the PTH groups respectively.
Negative_regulation (decreases) of Positive_regulation (increase) of BMD
5) Confidence 0.02 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936264 Disease Relevance 0 Pain Relevance 0

General Comments

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