INT211082

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.18
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) nuclear chromosome (Vdr) aging (Vdr)
cell morphogenesis (Vdr) nucleus (Vdr) DNA binding (Vdr)
Anatomy Link Frequency
smooth muscle cells 4
parathyroid 2
Vdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 65.60 Quite High
Pain 3 5.40 Low Low
fibrosis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 99 96.48 Very High Very High Very High
Calcification 15 94.04 High High
Chronic Renal Failure 84 77.56 Quite High
Atherosclerosis 9 76.56 Quite High
Hyperplasia 6 74.48 Quite High
Renal Disease 9 52.72 Quite High
Uremia 3 16.96 Low Low
Disease 9 10.44 Low Low
Pruritus 3 6.20 Low Low
Pain 3 5.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analogs of active vitamin D were developed to inhibit parathyroid secretion while minimizing the effects of vitamin D receptor activation elsewhere.
Regulation (effects) of Positive_regulation (activation) of vitamin D receptor in parathyroid
1) Confidence 0.30 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.27 Pain Relevance 0
Activation of the vitamin D receptor (VDR) on vascular smooth muscle cells has been found to regulate the synthesis of type 1 collagen, core binding factor alpha and bone morphogenic protein 2 – all of which contribute to the development of arterial calcification and mineralization (Virdi et al 1998; Bellows et al 1999; Drissi et al 2002).
Regulation (regulate) of Positive_regulation (Activation) of VDR in smooth muscle cells associated with calcification
2) Confidence 0.30 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.45 Pain Relevance 0.03
Activation of the vitamin D receptor (VDR) on vascular smooth muscle cells has been found to regulate the synthesis of type 1 collagen, core binding factor alpha and bone morphogenic protein 2 – all of which contribute to the development of arterial calcification and mineralization (Virdi et al 1998; Bellows et al 1999; Drissi et al 2002).
Regulation (regulate) of Positive_regulation (Activation) of vitamin D receptor in smooth muscle cells associated with calcification
3) Confidence 0.30 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.45 Pain Relevance 0.03

General Comments

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