INT2111

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Context Info
Confidence 0.77
First Reported 1977
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 34
Total Number 55
Disease Relevance 16.82
Pain Relevance 6.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LIF) extracellular region (LIF)
Anatomy Link Frequency
blood 4
epithelial cells 3
lymphocytes 3
macrophage 2
endometrium 2
LIF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 507 100.00 Very High Very High Very High
Raphe 3 99.32 Very High Very High Very High
halothane 11 98.76 Very High Very High Very High
spinal inflammation 18 98.58 Very High Very High Very High
aspirin 10 98.44 Very High Very High Very High
anesthesia 16 98.36 Very High Very High Very High
endometriosis 228 98.12 Very High Very High Very High
Inflammation 377 94.36 High High
Arthritis 82 91.08 High High
ketamine 2 91.04 High High
Disease Link Frequency Relevance Heat
Leukemia 101 100.00 Very High Very High Very High
Diphtheria 24 100.00 Very High Very High Very High
Respiratory Syncytial Virus 3 99.84 Very High Very High Very High
Carcinoma 84 99.42 Very High Very High Very High
Reprotox - General 3 168 99.30 Very High Very High Very High
Lung Cancer 80 98.60 Very High Very High Very High
Low Back Pain 18 98.58 Very High Very High Very High
Endometriosis 262 98.12 Very High Very High Very High
Hypoxia 26 97.28 Very High Very High Very High
Influenza Virus Infection 3 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leukaemia inhibitory factor (LIF) is produced by natural killer lymphocytes that interact with the invading trophoblast.
Gene_expression (produced) of LIF in lymphocytes associated with leukemia
1) Confidence 0.77 Published 2005 Journal Reprod. Biomed. Online Section Abstract Doc Link 16274610 Disease Relevance 0.39 Pain Relevance 0.13
The cytotoxic properties of DT-(1-389)-LIF-(2-184)-peptide may be useful in selectively depleting neuronal and immune cell populations that express the LIF beta receptor.
Gene_expression (express) of LIF in neuronal
2) Confidence 0.76 Published 1996 Journal Eur. J. Biochem. Section Abstract Doc Link 8917449 Disease Relevance 0.33 Pain Relevance 0
However, LIF expression was associated with pregnancy, and patients expressing strong LIF immunolabel in the endometrium were 6.4 times likely to achieve pregnancy than those with weak or mild staining [12].


Gene_expression (expression) of LIF in endometrium
3) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.21 Pain Relevance 0.03
The apparent independent expression of CLDN4 and LIF suggests that they may be controlled by different pathways, triggered by the balanced relationship between progesterone receptors A and B [3] Though the expression of CLDN4 and LIF appear unrelated, a survey of independent pathways related to the implantation phenomenon might be advantageous for the assessment of IVF success.
Gene_expression (expression) of LIF
4) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
In addition, previously published endometrial LIF immunolabeling data from the same group of patients [12] were combined with CLDN4 immunolabeling data, to determine coincident CLDN4/LIF expression patterns.
Spec (determine) Gene_expression (expression) of LIF
5) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
Our data show that the association of strong CLDN4 immunolabeling with non-pregnancy is weakened by the strong expression of LIF immunolabeling.
Gene_expression (expression) of LIF
6) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
The apparent independent expression of CLDN4 and LIF suggests that they may be controlled by different pathways, triggered by the balanced relationship between progesterone receptors A and B [3] Though the expression of CLDN4 and LIF appear unrelated, a survey of independent pathways related to the implantation phenomenon might be advantageous for the assessment of IVF success.
Gene_expression (expression) of LIF
7) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
Our data suggest that compensation for low LIF expression may increase pregnancy chances, and possibly counteract equally unfavorable high levels of endometrial CLDN4.
Gene_expression (expression) of LIF
8) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.08 Pain Relevance 0
The current understanding that embryonically-derived hCG upregulates expression of endometrial LIF [25], and that local instillation of hCG increases LIF expression [26], supports a therapeutic approach of worthy of further investigation.
Gene_expression (expression) of LIF
9) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.06 Pain Relevance 0
CDF and CTF were detectable within 20 min of the start of halothane anesthesia in every patient receiving halothane.
Gene_expression (detectable) of CDF associated with anesthesia and halothane
10) Confidence 0.75 Published 1987 Journal Anesth. Analg. Section Abstract Doc Link 3565792 Disease Relevance 0.07 Pain Relevance 0.67
When large doses of various Klebs cell envelope structures were used, MNC from all healthy blood donors were stimulated to produce LIF but not to synthesize significant amounts of DNA.
Gene_expression (produce) of LIF in blood
11) Confidence 0.73 Published 1986 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 3100299 Disease Relevance 0.53 Pain Relevance 0.39
For a highly sensitive analysis, LIF detection was also examined using a two-step precolumn derivatization procedure.
Spec (examined) Gene_expression (detection) of LIF
12) Confidence 0.67 Published 2004 Journal Electrophoresis Section Abstract Doc Link 15188246 Disease Relevance 0 Pain Relevance 0.26
The present study describes the genetic construction, expression, purification and properties of a diphtheria-toxin-related LIF gene fusion in which the native receptor-binding domain of diphtheria toxin was replaced with a gene encoding human LIF.
Gene_expression (expression) of LIF associated with diphtheria
13) Confidence 0.66 Published 1996 Journal Eur. J. Biochem. Section Abstract Doc Link 8917449 Disease Relevance 0.58 Pain Relevance 0
The present study describes the genetic construction, expression, purification and properties of a diphtheria-toxin-related LIF gene fusion in which the native receptor-binding domain of diphtheria toxin was replaced with a gene encoding human LIF.
Gene_expression (expression) of LIF associated with diphtheria
14) Confidence 0.66 Published 1996 Journal Eur. J. Biochem. Section Abstract Doc Link 8917449 Disease Relevance 0.51 Pain Relevance 0
The current understanding that embryonically-derived hCG upregulates expression of endometrial LIF [25], and that local instillation of hCG increases LIF expression [26], supports a therapeutic approach of worthy of further investigation.
Gene_expression (expression) of LIF
15) Confidence 0.66 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.07 Pain Relevance 0
However, LIF expression was associated with pregnancy, and patients expressing strong LIF immunolabel in the endometrium were 6.4 times likely to achieve pregnancy than those with weak or mild staining [12].


Gene_expression (expressing) of LIF in endometrium
16) Confidence 0.66 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.11 Pain Relevance 0
CLDN4/LIF category and patient parameters
Gene_expression (category) of LIF
17) Confidence 0.65 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.08 Pain Relevance 0
At the opposite extreme, patients exhibiting CLDN4+/LIF-endometrial immunolabeling showed much less pregnancy success.
Gene_expression (exhibiting) of LIF
18) Confidence 0.65 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
A review of LIF immunolabeling in stages of luteal phase
Gene_expression (immunolabeling) of LIF
19) Confidence 0.65 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.49 Pain Relevance 0.04
Furthermore, patients exhibiting CLDN4+/LIF- endometrial immunolabeling showed 0.71 less chance of pregnancy compared to those with CLDN4-/LIF- immunolabeling, but this odds ratio was not significant (p = 0.16; 95% CI = 0.05, 1.67).
Gene_expression (exhibiting) of LIF
20) Confidence 0.65 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0

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