INT211127

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) mitochondrion (MTX1)
extracellular region (TNF) plasma membrane (TNF) intracellular (TNF)
MTX1 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 50 100.00 Very High Very High Very High
antagonist 23 100.00 Very High Very High Very High
rheumatoid arthritis 56 98.40 Very High Very High Very High
Adalimumab 129 95.20 Very High Very High Very High
corticosteroid 1 37.24 Quite Low
Rheumatism 1 34.16 Quite Low
Arthritis 26 5.00 Very Low Very Low Very Low
spinal inflammation 21 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Etanercept 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 57 98.40 Very High Very High Very High
Disease 26 94.24 High High
Disease Progression 4 88.68 High High
Rheumatic Diseases 1 34.16 Quite Low
Fatigue 2 16.96 Low Low
Chronic Disease 1 16.32 Low Low
Low Back Pain 25 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 21 5.00 Very Low Very Low Very Low
Infection 10 5.00 Very Low Very Low Very Low
Mycobacterial Infection 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of ARMADA and DE019 confirm other studies showing that TNF antagonists in combination with MTX are more effective in the relief of signs and symptoms of RA and in inhibiting radiographic progression than MTX monotherapy, even in patients with long-standing disease.


Regulation (effective) of MTX Binding (combination) of TNF associated with antagonist, rheumatoid arthritis, disease and methotrexate
1) Confidence 0.22 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936294 Disease Relevance 0.71 Pain Relevance 0.74

General Comments

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