INT211131

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.45
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTX1)
MTX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 152 100.00 Very High Very High Very High
rheumatoid arthritis 128 100.00 Very High Very High Very High
Adalimumab 258 99.96 Very High Very High Very High
antagonist 46 99.32 Very High Very High Very High
Bioavailability 2 89.44 High High
Etanercept 14 72.00 Quite High
Infliximab 12 71.04 Quite High
metalloproteinase 14 55.88 Quite High
Rheumatism 3 41.68 Quite Low
corticosteroid 3 35.28 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 130 100.00 Very High Very High Very High
Disease 64 98.00 Very High Very High Very High
Disease Progression 8 86.72 High High
Adhesions 8 70.16 Quite High
Rheumatic Diseases 3 41.68 Quite Low
INFLAMMATION 17 34.96 Quite Low
Cancer 13 30.96 Quite Low
Necrosis 9 30.48 Quite Low
Fatigue 5 15.00 Low Low
Chronic Disease 3 14.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of ARMADA and DE019 confirm other studies showing that TNF antagonists in combination with MTX are more effective in the relief of signs and symptoms of RA and in inhibiting radiographic progression than MTX monotherapy, even in patients with long-standing disease.


Regulation (effective) of Gene_expression (progression) of MTX associated with antagonist, rheumatoid arthritis, disease and methotrexate
1) Confidence 0.21 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936294 Disease Relevance 0.75 Pain Relevance 0.71
Concomitant MTX administration does not adversely affect adalimumab serum concentrations; adalimumab had an average steady-state serum concentration of 5mg/mL and 8–9 ?
Neg (not) Regulation (affect) of Gene_expression (administration) of MTX associated with adalimumab and methotrexate
2) Confidence 0.21 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936294 Disease Relevance 0.50 Pain Relevance 0.80
For both rituximab + MTX dose groups there were significantly greater mean decreases in all individual components of the ACR core set (p?
Regulation (were) of Gene_expression (groups) of MTX associated with methotrexate
3) Confidence 0.10 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2938895 Disease Relevance 0.20 Pain Relevance 0.46

General Comments

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